Perspective on human papillomavirus infection treatment by vaginal microbiota
Abstract Cervical cancer continues to be a major public health problem affecting middle‐aged women. Almost all cervical cancers are caused by infection of high‐risk human papillomaviruses (hr‐HPV), thus tremendous efforts have been paid to accelerate the clearance of HPV. Vaginal microbiota has been...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-04-01
|
| Series: | Interdisciplinary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/INMD.20220020 |
| _version_ | 1827893378655715328 |
|---|---|
| author | Lingyan Zhong Jianxujie Zheng Ling Lin Qing Cong Liang Qiao |
| author_facet | Lingyan Zhong Jianxujie Zheng Ling Lin Qing Cong Liang Qiao |
| author_sort | Lingyan Zhong |
| collection | DOAJ |
| description | Abstract Cervical cancer continues to be a major public health problem affecting middle‐aged women. Almost all cervical cancers are caused by infection of high‐risk human papillomaviruses (hr‐HPV), thus tremendous efforts have been paid to accelerate the clearance of HPV. Vaginal microbiota has been considered to play a vital role in the regulation of cervical health, including HPV clearance. Several studies have focused on the relief of HPV‐related indicators using various microbes from vaginal microbiota, but the mechanism underlined is not fully understood. This perspective summarizes the current in vitro and in vivo experiments as well as clinical trials on the applications of vaginal microbiota to treat HPV infection and proposes topics that can be studied in the future. It is expected that more studies on the mechanism of vaginal microbiota‐regulated HPV infection treatment using in vivo and in vitro models, as well as more clinical trials using various microbes for HPV clearance will be carried out in the future. |
| first_indexed | 2024-03-12T21:52:20Z |
| format | Article |
| id | doaj.art-867acdf806fe49e58c05c5e95c8ffa63 |
| institution | Directory Open Access Journal |
| issn | 2832-6245 |
| language | English |
| last_indexed | 2024-03-12T21:52:20Z |
| publishDate | 2023-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Interdisciplinary Medicine |
| spelling | doaj.art-867acdf806fe49e58c05c5e95c8ffa632023-07-26T01:35:59ZengWiley-VCHInterdisciplinary Medicine2832-62452023-04-0112n/an/a10.1002/INMD.20220020Perspective on human papillomavirus infection treatment by vaginal microbiotaLingyan Zhong0Jianxujie Zheng1Ling Lin2Qing Cong3Liang Qiao4Department of Chemistry Zhongshan Hospital, and Obstetrics and Gynecology Hospital Fudan University Shanghai ChinaDepartment of Chemistry Zhongshan Hospital, and Obstetrics and Gynecology Hospital Fudan University Shanghai ChinaDepartment of Chemistry Zhongshan Hospital, and Obstetrics and Gynecology Hospital Fudan University Shanghai ChinaDepartment of Chemistry Zhongshan Hospital, and Obstetrics and Gynecology Hospital Fudan University Shanghai ChinaDepartment of Chemistry Zhongshan Hospital, and Obstetrics and Gynecology Hospital Fudan University Shanghai ChinaAbstract Cervical cancer continues to be a major public health problem affecting middle‐aged women. Almost all cervical cancers are caused by infection of high‐risk human papillomaviruses (hr‐HPV), thus tremendous efforts have been paid to accelerate the clearance of HPV. Vaginal microbiota has been considered to play a vital role in the regulation of cervical health, including HPV clearance. Several studies have focused on the relief of HPV‐related indicators using various microbes from vaginal microbiota, but the mechanism underlined is not fully understood. This perspective summarizes the current in vitro and in vivo experiments as well as clinical trials on the applications of vaginal microbiota to treat HPV infection and proposes topics that can be studied in the future. It is expected that more studies on the mechanism of vaginal microbiota‐regulated HPV infection treatment using in vivo and in vitro models, as well as more clinical trials using various microbes for HPV clearance will be carried out in the future.https://doi.org/10.1002/INMD.20220020cervicovaginal microenvironmentHPV clearancehuman papillomavirus (HPV) infectionvaginal microbiota |
| spellingShingle | Lingyan Zhong Jianxujie Zheng Ling Lin Qing Cong Liang Qiao Perspective on human papillomavirus infection treatment by vaginal microbiota Interdisciplinary Medicine cervicovaginal microenvironment HPV clearance human papillomavirus (HPV) infection vaginal microbiota |
| title | Perspective on human papillomavirus infection treatment by vaginal microbiota |
| title_full | Perspective on human papillomavirus infection treatment by vaginal microbiota |
| title_fullStr | Perspective on human papillomavirus infection treatment by vaginal microbiota |
| title_full_unstemmed | Perspective on human papillomavirus infection treatment by vaginal microbiota |
| title_short | Perspective on human papillomavirus infection treatment by vaginal microbiota |
| title_sort | perspective on human papillomavirus infection treatment by vaginal microbiota |
| topic | cervicovaginal microenvironment HPV clearance human papillomavirus (HPV) infection vaginal microbiota |
| url | https://doi.org/10.1002/INMD.20220020 |
| work_keys_str_mv | AT lingyanzhong perspectiveonhumanpapillomavirusinfectiontreatmentbyvaginalmicrobiota AT jianxujiezheng perspectiveonhumanpapillomavirusinfectiontreatmentbyvaginalmicrobiota AT linglin perspectiveonhumanpapillomavirusinfectiontreatmentbyvaginalmicrobiota AT qingcong perspectiveonhumanpapillomavirusinfectiontreatmentbyvaginalmicrobiota AT liangqiao perspectiveonhumanpapillomavirusinfectiontreatmentbyvaginalmicrobiota |