Seroprevalence of human enterovirus A71 in Guangzhou, China, 2019–2021
Enterovirus A71 (EV-A71) is a significant hand-foot-mouth disease (HFMD) etiology. The inactivated EV-A71 vaccines were approved in China in 2016. However, the seroprevalence of EV-A71 after the vaccine application and its potential association with the EV-A71 epidemic in the population are rarely s...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Biosafety and Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590053623000526 |
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| author | Huimin Lian Huimin Jiang Lina Yi Jing Sun Huaping Xie Ming Qiu Limei Sun Huifang Lin Mingda Yang Lin Qu Haiyi Yang Jing Lu Hanri Zeng |
| author_facet | Huimin Lian Huimin Jiang Lina Yi Jing Sun Huaping Xie Ming Qiu Limei Sun Huifang Lin Mingda Yang Lin Qu Haiyi Yang Jing Lu Hanri Zeng |
| author_sort | Huimin Lian |
| collection | DOAJ |
| description | Enterovirus A71 (EV-A71) is a significant hand-foot-mouth disease (HFMD) etiology. The inactivated EV-A71 vaccines were approved in China in 2016. However, the seroprevalence of EV-A71 after the vaccine application and its potential association with the EV-A71 epidemic in the population are rarely studied. In this study, we analyzed the incidence of EV-A71 infection and seroepidemiology in Guangzhou City, China. From 2019 to 2021, 167,920 clinically confirmed HFMD cases were reported in Guangzhou. In 6,868 enterovirus-positive samples, Coxsackievirus A6 and Coxsackievirus A16 were dominant genotypes, and only 3 EV-A71-positive samples were detected, highlighting the deficient epidemic activity of EV-A71. Microneutralization assay was performed on 1,000 representative serum samples. Notably, the seroprevalence and geometric mean titer (GMT) decreased significantly in 2020, and that in the < 3-year age group were increased and even higher than that in 3–5-year age group in 2019 and 2021, which was contrary to our previous surveillance result and other studies in Guangzhou. Furthermore, a moderate decline of GMT level was observed following the vaccination, but the seropositive serums were still detected for 49 months after second immunization, suggesting the long-term persistence of the immunity. Our seroepidemiology study revealed relatively higher neutralizing antibody activity in the susceptible population after the EV-A71 vaccine was adopted in 2016 in Guangzhou. It may be one of the reasons for the lower epidemic activity of EV-A71 in Guangzhou from 2019 to 2021. |
| first_indexed | 2024-03-13T03:28:27Z |
| format | Article |
| id | doaj.art-867af701da8e407591e1899b1f76fb2e |
| institution | Directory Open Access Journal |
| issn | 2590-0536 |
| language | English |
| last_indexed | 2024-03-13T03:28:27Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
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| series | Biosafety and Health |
| spelling | doaj.art-867af701da8e407591e1899b1f76fb2e2023-06-25T04:43:29ZengElsevierBiosafety and Health2590-05362023-06-0153168173Seroprevalence of human enterovirus A71 in Guangzhou, China, 2019–2021Huimin Lian0Huimin Jiang1Lina Yi2Jing Sun3Huaping Xie4Ming Qiu5Limei Sun6Huifang Lin7Mingda Yang8Lin Qu9Haiyi Yang10Jing Lu11Hanri Zeng12School of Public Health, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, ChinaSchool of Public Health, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, ChinaGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, ChinaHealth Commission of Heping District, Shenyang City, Liaoning 110003, ChinaGuangzhou Center for Disease Control and Prevention, Guangzhou 510440, ChinaGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; School of Public Health, Sun Yat-Sen University, Guangzhou 510080, ChinaGuangdong Workstation for Emerging Infectious Disease Control and Prevention, Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, ChinaGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, ChinaGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; School of Public Health, Jinan University, Guangzhou 510632, ChinaGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; School of Public Health, Sun Yat-Sen University, Guangzhou 510080, ChinaGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; School of Public Health, Sun Yat-Sen University, Guangzhou 510080, ChinaSchool of Public Health, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; Corresponding authors: School of Public Health, Southern Medical University, Guangzhou 510515, China (J. Lu); Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China (H. Zeng).Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Guangdong Provincial Key Laboratory of Pathogen Detection for Emerging Infectious Disease Response, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China; Corresponding authors: School of Public Health, Southern Medical University, Guangzhou 510515, China (J. Lu); Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China (H. Zeng).Enterovirus A71 (EV-A71) is a significant hand-foot-mouth disease (HFMD) etiology. The inactivated EV-A71 vaccines were approved in China in 2016. However, the seroprevalence of EV-A71 after the vaccine application and its potential association with the EV-A71 epidemic in the population are rarely studied. In this study, we analyzed the incidence of EV-A71 infection and seroepidemiology in Guangzhou City, China. From 2019 to 2021, 167,920 clinically confirmed HFMD cases were reported in Guangzhou. In 6,868 enterovirus-positive samples, Coxsackievirus A6 and Coxsackievirus A16 were dominant genotypes, and only 3 EV-A71-positive samples were detected, highlighting the deficient epidemic activity of EV-A71. Microneutralization assay was performed on 1,000 representative serum samples. Notably, the seroprevalence and geometric mean titer (GMT) decreased significantly in 2020, and that in the < 3-year age group were increased and even higher than that in 3–5-year age group in 2019 and 2021, which was contrary to our previous surveillance result and other studies in Guangzhou. Furthermore, a moderate decline of GMT level was observed following the vaccination, but the seropositive serums were still detected for 49 months after second immunization, suggesting the long-term persistence of the immunity. Our seroepidemiology study revealed relatively higher neutralizing antibody activity in the susceptible population after the EV-A71 vaccine was adopted in 2016 in Guangzhou. It may be one of the reasons for the lower epidemic activity of EV-A71 in Guangzhou from 2019 to 2021.http://www.sciencedirect.com/science/article/pii/S2590053623000526Enterovirus A71VaccineSeroepidemiology |
| spellingShingle | Huimin Lian Huimin Jiang Lina Yi Jing Sun Huaping Xie Ming Qiu Limei Sun Huifang Lin Mingda Yang Lin Qu Haiyi Yang Jing Lu Hanri Zeng Seroprevalence of human enterovirus A71 in Guangzhou, China, 2019–2021 Biosafety and Health Enterovirus A71 Vaccine Seroepidemiology |
| title | Seroprevalence of human enterovirus A71 in Guangzhou, China, 2019–2021 |
| title_full | Seroprevalence of human enterovirus A71 in Guangzhou, China, 2019–2021 |
| title_fullStr | Seroprevalence of human enterovirus A71 in Guangzhou, China, 2019–2021 |
| title_full_unstemmed | Seroprevalence of human enterovirus A71 in Guangzhou, China, 2019–2021 |
| title_short | Seroprevalence of human enterovirus A71 in Guangzhou, China, 2019–2021 |
| title_sort | seroprevalence of human enterovirus a71 in guangzhou china 2019 2021 |
| topic | Enterovirus A71 Vaccine Seroepidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S2590053623000526 |
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