Performance scaling and trade-offs for collective motor-driven transport

Motor-driven intracellular transport of organelles, vesicles, and other molecular cargo is a highly collective process. An individual cargo is often pulled by a team of transport motors, with numbers ranging from only a few to several hundred. We explore the behavior of these systems using a stochas...

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Bibliographic Details
Main Authors: Matthew P Leighton, David A Sivak
Format: Article
Language:English
Published: IOP Publishing 2022-01-01
Series:New Journal of Physics
Subjects:
Online Access:https://doi.org/10.1088/1367-2630/ac3db7
Description
Summary:Motor-driven intracellular transport of organelles, vesicles, and other molecular cargo is a highly collective process. An individual cargo is often pulled by a team of transport motors, with numbers ranging from only a few to several hundred. We explore the behavior of these systems using a stochastic model for transport of molecular cargo by an arbitrary number N of motors obeying linear Langevin dynamics, finding analytic solutions for the N -dependence of the velocity, precision of forward progress, energy flows between different system components, and efficiency. In two opposing regimes, we show that these properties obey simple scaling laws with N . Finally, we explore trade-offs between performance metrics as N is varied, providing insight into how different numbers of motors might be well-matched to distinct contexts where different performance metrics are prioritized.
ISSN:1367-2630