Performance scaling and trade-offs for collective motor-driven transport
Motor-driven intracellular transport of organelles, vesicles, and other molecular cargo is a highly collective process. An individual cargo is often pulled by a team of transport motors, with numbers ranging from only a few to several hundred. We explore the behavior of these systems using a stochas...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2022-01-01
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| Series: | New Journal of Physics |
| Subjects: | |
| Online Access: | https://doi.org/10.1088/1367-2630/ac3db7 |
| _version_ | 1797748569583648768 |
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| author | Matthew P Leighton David A Sivak |
| author_facet | Matthew P Leighton David A Sivak |
| author_sort | Matthew P Leighton |
| collection | DOAJ |
| description | Motor-driven intracellular transport of organelles, vesicles, and other molecular cargo is a highly collective process. An individual cargo is often pulled by a team of transport motors, with numbers ranging from only a few to several hundred. We explore the behavior of these systems using a stochastic model for transport of molecular cargo by an arbitrary number N of motors obeying linear Langevin dynamics, finding analytic solutions for the N -dependence of the velocity, precision of forward progress, energy flows between different system components, and efficiency. In two opposing regimes, we show that these properties obey simple scaling laws with N . Finally, we explore trade-offs between performance metrics as N is varied, providing insight into how different numbers of motors might be well-matched to distinct contexts where different performance metrics are prioritized. |
| first_indexed | 2024-03-12T16:06:40Z |
| format | Article |
| id | doaj.art-867bf9ca21424ef69c684c463eca73f6 |
| institution | Directory Open Access Journal |
| issn | 1367-2630 |
| language | English |
| last_indexed | 2024-03-12T16:06:40Z |
| publishDate | 2022-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | New Journal of Physics |
| spelling | doaj.art-867bf9ca21424ef69c684c463eca73f62023-08-09T14:19:12ZengIOP PublishingNew Journal of Physics1367-26302022-01-0124101300910.1088/1367-2630/ac3db7Performance scaling and trade-offs for collective motor-driven transportMatthew P Leighton0https://orcid.org/0000-0002-4765-9967David A Sivak1https://orcid.org/0000-0003-4815-4722Department of Physics, Simon Fraser University , Burnaby, British Columbia, V5A 1S6, CanadaDepartment of Physics, Simon Fraser University , Burnaby, British Columbia, V5A 1S6, CanadaMotor-driven intracellular transport of organelles, vesicles, and other molecular cargo is a highly collective process. An individual cargo is often pulled by a team of transport motors, with numbers ranging from only a few to several hundred. We explore the behavior of these systems using a stochastic model for transport of molecular cargo by an arbitrary number N of motors obeying linear Langevin dynamics, finding analytic solutions for the N -dependence of the velocity, precision of forward progress, energy flows between different system components, and efficiency. In two opposing regimes, we show that these properties obey simple scaling laws with N . Finally, we explore trade-offs between performance metrics as N is varied, providing insight into how different numbers of motors might be well-matched to distinct contexts where different performance metrics are prioritized.https://doi.org/10.1088/1367-2630/ac3db7molecular motorscollective transportLangevin equationstochastic thermodynamicsfluctuations |
| spellingShingle | Matthew P Leighton David A Sivak Performance scaling and trade-offs for collective motor-driven transport New Journal of Physics molecular motors collective transport Langevin equation stochastic thermodynamics fluctuations |
| title | Performance scaling and trade-offs for collective motor-driven transport |
| title_full | Performance scaling and trade-offs for collective motor-driven transport |
| title_fullStr | Performance scaling and trade-offs for collective motor-driven transport |
| title_full_unstemmed | Performance scaling and trade-offs for collective motor-driven transport |
| title_short | Performance scaling and trade-offs for collective motor-driven transport |
| title_sort | performance scaling and trade offs for collective motor driven transport |
| topic | molecular motors collective transport Langevin equation stochastic thermodynamics fluctuations |
| url | https://doi.org/10.1088/1367-2630/ac3db7 |
| work_keys_str_mv | AT matthewpleighton performancescalingandtradeoffsforcollectivemotordriventransport AT davidasivak performancescalingandtradeoffsforcollectivemotordriventransport |