l-Fucose ameliorates high-fat diet-induced obesity and hepatic steatosis in mice
Abstract Background l-Fucose (Fuc), a six-deoxy hexose monosaccharide, is present endogenously in humans and animals and has a wide range of biological functions. In the present study, we aimed to examine the effect of Fuc on obesity and hepatic steatosis in mice fed a high-fat diet (HFD). Methods C...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-12-01
|
| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12967-018-1718-x |
| _version_ | 1818296512443056128 |
|---|---|
| author | Guangyan Wu Mengwei Niu Wenli Tang Jingjuan Hu Guoquan Wei Zhanke He Yangping Chen Yong Jiang Peng Chen |
| author_facet | Guangyan Wu Mengwei Niu Wenli Tang Jingjuan Hu Guoquan Wei Zhanke He Yangping Chen Yong Jiang Peng Chen |
| author_sort | Guangyan Wu |
| collection | DOAJ |
| description | Abstract Background l-Fucose (Fuc), a six-deoxy hexose monosaccharide, is present endogenously in humans and animals and has a wide range of biological functions. In the present study, we aimed to examine the effect of Fuc on obesity and hepatic steatosis in mice fed a high-fat diet (HFD). Methods C57BL/6 mice were fed a normal chow (NC) or HFD for 18 weeks to induce obesity and fatty liver. Fuc was administered intragastrically from the 8th week to the end of the experiment (18 weeks). Results Metagenomic analysis showed that HFD altered the genomic profile of gut microbiota in the mice; specifically, expression of alpha-l-fucosidase, the gene responsible for Fuc generation, was markedly reduced in the HFD group compared with that in the NC group. Fuc treatment decreased body weight gain, fat accumulation, and hepatic triglyceride elevation in HFD-fed mice. In addition, Fuc decreased the levels of endotoxin-producing bacteria of the Desulfovibrionaceae family and restored HFD-induced enteric dysbiosis at both compositional and functional levels. Conclusion Our findings suggest that Fuc might be a novel strategy to treat HFD-induced obesity and fatty liver. |
| first_indexed | 2024-12-13T04:04:43Z |
| format | Article |
| id | doaj.art-867d210dcc494fa69dccc8effeb79fa5 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-13T04:04:43Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-867d210dcc494fa69dccc8effeb79fa52022-12-22T00:00:16ZengBMCJournal of Translational Medicine1479-58762018-12-0116111210.1186/s12967-018-1718-xl-Fucose ameliorates high-fat diet-induced obesity and hepatic steatosis in miceGuangyan Wu0Mengwei Niu1Wenli Tang2Jingjuan Hu3Guoquan Wei4Zhanke He5Yangping Chen6Yong Jiang7Peng Chen8Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical UniversityDepartment of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical UniversityDivision of Laboratory Medicine, Zhujiang Hospital, Southern Medical UniversityDepartment of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical UniversityDepartment of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical UniversityDepartment of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical UniversityDepartment of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical UniversityDepartment of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical UniversityDepartment of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical UniversityAbstract Background l-Fucose (Fuc), a six-deoxy hexose monosaccharide, is present endogenously in humans and animals and has a wide range of biological functions. In the present study, we aimed to examine the effect of Fuc on obesity and hepatic steatosis in mice fed a high-fat diet (HFD). Methods C57BL/6 mice were fed a normal chow (NC) or HFD for 18 weeks to induce obesity and fatty liver. Fuc was administered intragastrically from the 8th week to the end of the experiment (18 weeks). Results Metagenomic analysis showed that HFD altered the genomic profile of gut microbiota in the mice; specifically, expression of alpha-l-fucosidase, the gene responsible for Fuc generation, was markedly reduced in the HFD group compared with that in the NC group. Fuc treatment decreased body weight gain, fat accumulation, and hepatic triglyceride elevation in HFD-fed mice. In addition, Fuc decreased the levels of endotoxin-producing bacteria of the Desulfovibrionaceae family and restored HFD-induced enteric dysbiosis at both compositional and functional levels. Conclusion Our findings suggest that Fuc might be a novel strategy to treat HFD-induced obesity and fatty liver.http://link.springer.com/article/10.1186/s12967-018-1718-xl-FucoseObesityHepatic steatosisHigh-fat dietGut microbiota |
| spellingShingle | Guangyan Wu Mengwei Niu Wenli Tang Jingjuan Hu Guoquan Wei Zhanke He Yangping Chen Yong Jiang Peng Chen l-Fucose ameliorates high-fat diet-induced obesity and hepatic steatosis in mice Journal of Translational Medicine l-Fucose Obesity Hepatic steatosis High-fat diet Gut microbiota |
| title | l-Fucose ameliorates high-fat diet-induced obesity and hepatic steatosis in mice |
| title_full | l-Fucose ameliorates high-fat diet-induced obesity and hepatic steatosis in mice |
| title_fullStr | l-Fucose ameliorates high-fat diet-induced obesity and hepatic steatosis in mice |
| title_full_unstemmed | l-Fucose ameliorates high-fat diet-induced obesity and hepatic steatosis in mice |
| title_short | l-Fucose ameliorates high-fat diet-induced obesity and hepatic steatosis in mice |
| title_sort | l fucose ameliorates high fat diet induced obesity and hepatic steatosis in mice |
| topic | l-Fucose Obesity Hepatic steatosis High-fat diet Gut microbiota |
| url | http://link.springer.com/article/10.1186/s12967-018-1718-x |
| work_keys_str_mv | AT guangyanwu lfucoseameliorateshighfatdietinducedobesityandhepaticsteatosisinmice AT mengweiniu lfucoseameliorateshighfatdietinducedobesityandhepaticsteatosisinmice AT wenlitang lfucoseameliorateshighfatdietinducedobesityandhepaticsteatosisinmice AT jingjuanhu lfucoseameliorateshighfatdietinducedobesityandhepaticsteatosisinmice AT guoquanwei lfucoseameliorateshighfatdietinducedobesityandhepaticsteatosisinmice AT zhankehe lfucoseameliorateshighfatdietinducedobesityandhepaticsteatosisinmice AT yangpingchen lfucoseameliorateshighfatdietinducedobesityandhepaticsteatosisinmice AT yongjiang lfucoseameliorateshighfatdietinducedobesityandhepaticsteatosisinmice AT pengchen lfucoseameliorateshighfatdietinducedobesityandhepaticsteatosisinmice |