In vivo inhibition of influenza A virus replication by RNA interference targeting the PB2 subunit via intratracheal delivery.

In vivo inhibition of influenza A virus replication by RNA interference targeting the PB2 subunit via intratracheal delivery.

Influenza virus infection is a major threat to human health. Small interfering RNA (siRNA) is a promising approach for the prevention and treatment of viral infections. In this study, we constructed a series of DNA vector-based short hairpin RNAs (shRNAs) that target various genes of the influenza A...

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Bibliographic Details
Main Authors: Daniel Tsung-Ning Huang, Chun-Yi Lu, Pei-Lan Shao, Luan-Yin Chang, Jin-Yuan Wang, Yi-Hsuan Chang, Mei-Ju Lai, Ya-Hui Chi, Li-Min Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5381882?pdf=render

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http://europepmc.org/articles/PMC5381882?pdf=render

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