Simplified Selection Criteria for Secondary Cytoreductive Surgery in Recurrent Ovarian Cancer
(1) Background: Multiple confounding factors influence the indications for secondary cytoreductive surgery (SCS) in patients with ovarian cancer (OC). We aimed to identify the factors associated with patients most likely to benefit from SCS. (2) Methods: We retrospectively reviewed the medical recor...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/16/3987 |
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| author | Joo-Hyuk Son Jimin Lee Sun-Hyung Yum Jeeyeon Kim Tae-Wook Kong Suk-Joon Chang Hee-Sug Ryu |
| author_facet | Joo-Hyuk Son Jimin Lee Sun-Hyung Yum Jeeyeon Kim Tae-Wook Kong Suk-Joon Chang Hee-Sug Ryu |
| author_sort | Joo-Hyuk Son |
| collection | DOAJ |
| description | (1) Background: Multiple confounding factors influence the indications for secondary cytoreductive surgery (SCS) in patients with ovarian cancer (OC). We aimed to identify the factors associated with patients most likely to benefit from SCS. (2) Methods: We retrospectively reviewed the medical records of patients with recurrent ovarian cancer from 2003 to 2021. The potential factors influencing treatment outcomes and survival between patients who received chemotherapy alone and those who received SCS after recurrence were evaluated. (3) Results: Recurrent OC was identified in 262 patients, with a median age of 53 (20–80) years. Of these patients, 87.4% had an initial stage III/IV disease. Eighty-nine (34%) patients received SCS. The median survival was 41.0 (95% confidence interval [CI], 37.4–44.5) months and 88.0 (95% CI, 64.2–111.7) months in the chemotherapy and surgery groups, respectively. A multivariate analysis showed limited regional carcinomatosis (single region or up to three regions with limited carcinomatosis) (<i>p</i> = 0.045) as the only significant factor for predicting no residual disease after SCS. In platinum-sensitive recurrent patients with limited regional recurrence, the complete resection rate was 87.6%. (4) Conclusions: SCS had a significant impact on survival in the selected patient population. Limited regional recurrence (single region or up to three regions with limited carcinomatosis) may be a simple criterion for SCS in platinum-sensitive recurrent OC patients. |
| first_indexed | 2024-03-09T09:59:36Z |
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| id | doaj.art-8680c9f8ddc5478897698d0a89295d98 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T09:59:36Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8680c9f8ddc5478897698d0a89295d982023-12-01T23:32:23ZengMDPI AGCancers2072-66942022-08-011416398710.3390/cancers14163987Simplified Selection Criteria for Secondary Cytoreductive Surgery in Recurrent Ovarian CancerJoo-Hyuk Son0Jimin Lee1Sun-Hyung Yum2Jeeyeon Kim3Tae-Wook Kong4Suk-Joon Chang5Hee-Sug Ryu6Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 16499, KoreaDepartment of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon 16499, KoreaDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 16499, KoreaDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 16499, KoreaDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 16499, KoreaDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon 16499, Korea(1) Background: Multiple confounding factors influence the indications for secondary cytoreductive surgery (SCS) in patients with ovarian cancer (OC). We aimed to identify the factors associated with patients most likely to benefit from SCS. (2) Methods: We retrospectively reviewed the medical records of patients with recurrent ovarian cancer from 2003 to 2021. The potential factors influencing treatment outcomes and survival between patients who received chemotherapy alone and those who received SCS after recurrence were evaluated. (3) Results: Recurrent OC was identified in 262 patients, with a median age of 53 (20–80) years. Of these patients, 87.4% had an initial stage III/IV disease. Eighty-nine (34%) patients received SCS. The median survival was 41.0 (95% confidence interval [CI], 37.4–44.5) months and 88.0 (95% CI, 64.2–111.7) months in the chemotherapy and surgery groups, respectively. A multivariate analysis showed limited regional carcinomatosis (single region or up to three regions with limited carcinomatosis) (<i>p</i> = 0.045) as the only significant factor for predicting no residual disease after SCS. In platinum-sensitive recurrent patients with limited regional recurrence, the complete resection rate was 87.6%. (4) Conclusions: SCS had a significant impact on survival in the selected patient population. Limited regional recurrence (single region or up to three regions with limited carcinomatosis) may be a simple criterion for SCS in platinum-sensitive recurrent OC patients.https://www.mdpi.com/2072-6694/14/16/3987advanced ovarian cancerrecurrent ovarian cancersecondary cytoreductive surgery |
| spellingShingle | Joo-Hyuk Son Jimin Lee Sun-Hyung Yum Jeeyeon Kim Tae-Wook Kong Suk-Joon Chang Hee-Sug Ryu Simplified Selection Criteria for Secondary Cytoreductive Surgery in Recurrent Ovarian Cancer Cancers advanced ovarian cancer recurrent ovarian cancer secondary cytoreductive surgery |
| title | Simplified Selection Criteria for Secondary Cytoreductive Surgery in Recurrent Ovarian Cancer |
| title_full | Simplified Selection Criteria for Secondary Cytoreductive Surgery in Recurrent Ovarian Cancer |
| title_fullStr | Simplified Selection Criteria for Secondary Cytoreductive Surgery in Recurrent Ovarian Cancer |
| title_full_unstemmed | Simplified Selection Criteria for Secondary Cytoreductive Surgery in Recurrent Ovarian Cancer |
| title_short | Simplified Selection Criteria for Secondary Cytoreductive Surgery in Recurrent Ovarian Cancer |
| title_sort | simplified selection criteria for secondary cytoreductive surgery in recurrent ovarian cancer |
| topic | advanced ovarian cancer recurrent ovarian cancer secondary cytoreductive surgery |
| url | https://www.mdpi.com/2072-6694/14/16/3987 |
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