DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells

DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells

Summary: To mount an efficient interferon response to virus infection, intracellular pattern recognition receptors (PRRs) sense viral nucleic acids and activate anti-viral gene transcription. The mechanisms by which intracellular DNA and DNA viruses are sensed are relevant not only to anti-viral inn...

Full description

Bibliographic Details
Main Authors:	Dayana B. Hristova, Marisa Oliveira, Emma Wagner, Alan Melcher, Kevin J. Harrington, Alexandre Belot, Brian J. Ferguson
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Series:	iScience
Subjects:	Virology Molecular biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004223028377

Similar Items

Serine metabolism is crucial for cGAS-STING signaling and viral defense control in the gut
by: Björn Becker, et al.
Published: (2024-03-01)

Kinetics of viral DNA in body fluids and antibody response in patients with acute Monkeypox virus infection
by: Francesca Colavita, et al.
Published: (2023-03-01)

Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict
by: James B Eaglesham, et al.
Published: (2020-11-01)

cGAS-independent STING activation in response to DNA damage
by: Leonie Unterholzner, et al.
Published: (2019-07-01)

Secrets of DNA-PKcs beyond DNA repair
by: Sydney Camfield, et al.
Published: (2024-07-01)

DNA-PKcs restricts Zika virus spreading and is required for effective antiviral response
by: Daniel de Oliveira Patricio, et al.
Published: (2022-10-01)

DNA-PKcs-dependent signaling of DNA damage in Dictyostelium discoideum.
by: Hudson, J, et al.
Published: (2005)

cGAS and STING: At the intersection of DNA and RNA virus-sensing networks.
by: Guoxin Ni, et al.
Published: (2018-08-01)

The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases
by: Zhilei Wang, et al.
Published: (2021-07-01)

Sensing of viral lung infections by cGAS-STING
by: Lei Fang, et al.
Published: (2022-05-01)

Viral ecology /
by: Hurst, Christon J.
Published: (2000)

Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
by: Jeonghan Kim, et al.
Published: (2023-03-01)

Comparison of DNA vaccines with AS03 as an adjuvant and an mRNA vaccine against SARS-CoV-2
by: Praveen Neeli, et al.
Published: (2023-07-01)

Lost in the bloom: DNA-PKcs in green plants
by: Koppolu Raja Rajesh Kumar
Published: (2023-07-01)

DNA-PKcs participated in hypoxic pulmonary hypertension
by: Ying-ying Liu, et al.
Published: (2022-09-01)

Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates
by: Mariana Marques, et al.
Published: (2024-03-01)

SENP3‐mediated TIP60 deSUMOylation is required for DNA‐PKcs activity and DNA damage repair
by: Yang Han, et al.
Published: (2022-06-01)

DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes.
by: Ara Kim Wiese, et al.
Published: (2017-01-01)

DNA-PKcs: A Multi-Faceted Player in DNA Damage Response
by: Xiaoqiao Yue, et al.
Published: (2020-12-01)

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
by: Jessica F. Almine, et al.
Published: (2017-02-01)

Trafficking and effect of released DNA on cGAS-STING signaling pathway and cardiovascular disease
by: Zimo Zhou, et al.
Published: (2023-12-01)

Protocol for Monitoring DNA-Triggered cGAS/STING Signaling in Mammalian Cells and Mice
by: Ying Wang, et al.
Published: (2020-12-01)

Self-DNA Sensing by cGAS-STING and TLR9 in Autoimmunity: Is the Cytoskeleton in Control?
by: Roberto Amadio, et al.
Published: (2021-05-01)

Mitochondrial DNA leakage induces odontoblast inflammation via the cGAS-STING pathway
by: Lu Zhou, et al.
Published: (2021-05-01)

Mosquito transgenerational antiviral immunity is mediated by vertical transfer of virus DNA sequences and RNAi
by: Julio Rodriguez-Andres, et al.
Published: (2024-01-01)

Impact of peripheral mitochondrial DNA level on immune response after COVID-19 vaccination
by: Hiroaki Ikezaki, et al.
Published: (2023-07-01)

Effects of altering CpG dinucleotide composition in small DNA viruses
by: Loew, L
Published: (2020)

The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation
by: Weijie Ouyang, et al.
Published: (2023-09-01)

STING nuclear partners contribute to innate immune signaling responses
by: Charles R. Dixon, et al.
Published: (2021-09-01)

Viral antagonism of extracellular cGAMP responses
by: Blest, HTW
Published: (2022)

The multifaceted functions of DNA‐PKcs: implications for the therapy of human diseases
by: Jinghong Wu, et al.
Published: (2024-07-01)

Gamma-Herpesvirus Latency Requires T Cell Evasion during Episome Maintenance
by: Bennett Neil J, et al.
Published: (2005-01-01)

Capture and inactivation of viral particles from bioaerosols by electrostatic precipitation
by: Hannah E. Preston, et al.
Published: (2023-09-01)

Integrated hepatitis B virus DNA maintains surface antigen production during antiviral treatment
by: Tanner Grudda, et al.
Published: (2022-09-01)

Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks
by: Pierre Caron, et al.
Published: (2015-11-01)

HIVIS-DNA or HIVISopt-DNA priming followed by CMDR vaccinia-based boosts induce both humoral and cellular murine immune responses to HIV
by: J Hinkula, et al.
Published: (2017-06-01)

The neuroimmune nexus: unraveling the role of the mtDNA-cGAS-STING signal pathway in Alzheimer’s disease
by: Shuiyue Quan, et al.
Published: (2025-03-01)

mtDNA release promotes cGAS-STING activation and accelerated aging of postmitotic muscle cells
by: Ying Li, et al.
Published: (2024-07-01)

Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging
by: Juan Ignacio Jiménez-Loygorri, et al.
Published: (2024-01-01)

The Innate Immune DNA Sensing cGAS-STING Signaling Pathway Mediates Anti-PRRSV Function
by: Yulin Xu, et al.
Published: (2021-09-01)