Bioactive limonoids from Carapa guianensis seeds oil and the sustainable use of its by-products
Carapa guianensis (Andiroba, Meliaceae) is considered a multipurpose tree. In Brazil, Indigenous people have used it as insect repellent and in the treatment of various diseases. Most biological activities and popular uses are attributed to limonoids, which are highly oxygenated tetranortriterpenoid...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Current Research in Toxicology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666027X23000026 |
| _version_ | 1797798610753028096 |
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| author | Vagner Pereira da Silva Lavínia de Carvalho Brito André Mesquita Marques Flávia da Cunha Camillo Maria Raquel Figueiredo |
| author_facet | Vagner Pereira da Silva Lavínia de Carvalho Brito André Mesquita Marques Flávia da Cunha Camillo Maria Raquel Figueiredo |
| author_sort | Vagner Pereira da Silva |
| collection | DOAJ |
| description | Carapa guianensis (Andiroba, Meliaceae) is considered a multipurpose tree. In Brazil, Indigenous people have used it as insect repellent and in the treatment of various diseases. Most biological activities and popular uses are attributed to limonoids, which are highly oxygenated tetranortriterpenoids. More than 300 limonoids have been described in Meliaceae family. Limonoids from Andiroba oil have shown high anti-inflammatory and anti-allergic activities in vivo, by inhibiting platelet activating factors and many inflammatory mediators such as IL-5, IL-1β and TNF-α. It also reduced T lymphocytes, eosinophils and mast cells. In corroboration with the wide popular use of Andiroba oil, no significant cytotoxicity or genotoxicity in vivo was reported. This oil promotes apoptosis in a gastric cancer cell line (ACP02) at high concentrations, without showing mutagenic effects, and is suggested to increase the body's nonspecific resistance and adaptive capacity to stressors, exhibit some antioxidant activity, and protect against oxidative DNA damages. Recently, new methodologies of toxicological assays have been applied. They include in chemico, in vitro, in silico and ex vivo procedures, and take place to substitute the use of laboratory animals. Andiroba by-products have been used in sustainable oil production processes and as fertilizers and soil conditioners, raw material for soap production, biodegradable surfactants and an alternative natural source of biodegradable polymer in order to reduce environmental impacts. This review reinforces the relevance of Andiroba and highlights its ability to add value to its by-products and to minimize possible risks to the health of the Amazonian population. |
| first_indexed | 2024-03-13T04:07:25Z |
| format | Article |
| id | doaj.art-8681459713604f80b0b73c57292afd3c |
| institution | Directory Open Access Journal |
| issn | 2666-027X |
| language | English |
| last_indexed | 2024-03-13T04:07:25Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Toxicology |
| spelling | doaj.art-8681459713604f80b0b73c57292afd3c2023-06-21T06:59:59ZengElsevierCurrent Research in Toxicology2666-027X2023-01-014100104Bioactive limonoids from Carapa guianensis seeds oil and the sustainable use of its by-productsVagner Pereira da Silva0Lavínia de Carvalho Brito1André Mesquita Marques2Flávia da Cunha Camillo3Maria Raquel Figueiredo4Corresponding author.; Laboratório de Produtos Naturais (TecBio), Instituto de Tecnologia em Fármacos, FIOCRUZ, Rua Sizenando Nabuco 100, Rio de Janeiro, RJ 21041-250, BrazilLaboratório de Produtos Naturais (TecBio), Instituto de Tecnologia em Fármacos, FIOCRUZ, Rua Sizenando Nabuco 100, Rio de Janeiro, RJ 21041-250, BrazilLaboratório de Produtos Naturais (TecBio), Instituto de Tecnologia em Fármacos, FIOCRUZ, Rua Sizenando Nabuco 100, Rio de Janeiro, RJ 21041-250, BrazilLaboratório de Produtos Naturais (TecBio), Instituto de Tecnologia em Fármacos, FIOCRUZ, Rua Sizenando Nabuco 100, Rio de Janeiro, RJ 21041-250, BrazilLaboratório de Produtos Naturais (TecBio), Instituto de Tecnologia em Fármacos, FIOCRUZ, Rua Sizenando Nabuco 100, Rio de Janeiro, RJ 21041-250, BrazilCarapa guianensis (Andiroba, Meliaceae) is considered a multipurpose tree. In Brazil, Indigenous people have used it as insect repellent and in the treatment of various diseases. Most biological activities and popular uses are attributed to limonoids, which are highly oxygenated tetranortriterpenoids. More than 300 limonoids have been described in Meliaceae family. Limonoids from Andiroba oil have shown high anti-inflammatory and anti-allergic activities in vivo, by inhibiting platelet activating factors and many inflammatory mediators such as IL-5, IL-1β and TNF-α. It also reduced T lymphocytes, eosinophils and mast cells. In corroboration with the wide popular use of Andiroba oil, no significant cytotoxicity or genotoxicity in vivo was reported. This oil promotes apoptosis in a gastric cancer cell line (ACP02) at high concentrations, without showing mutagenic effects, and is suggested to increase the body's nonspecific resistance and adaptive capacity to stressors, exhibit some antioxidant activity, and protect against oxidative DNA damages. Recently, new methodologies of toxicological assays have been applied. They include in chemico, in vitro, in silico and ex vivo procedures, and take place to substitute the use of laboratory animals. Andiroba by-products have been used in sustainable oil production processes and as fertilizers and soil conditioners, raw material for soap production, biodegradable surfactants and an alternative natural source of biodegradable polymer in order to reduce environmental impacts. This review reinforces the relevance of Andiroba and highlights its ability to add value to its by-products and to minimize possible risks to the health of the Amazonian population.http://www.sciencedirect.com/science/article/pii/S2666027X23000026AndirobaMeliaceaeInsecticideMedicinal Plant |
| spellingShingle | Vagner Pereira da Silva Lavínia de Carvalho Brito André Mesquita Marques Flávia da Cunha Camillo Maria Raquel Figueiredo Bioactive limonoids from Carapa guianensis seeds oil and the sustainable use of its by-products Current Research in Toxicology Andiroba Meliaceae Insecticide Medicinal Plant |
| title | Bioactive limonoids from Carapa guianensis seeds oil and the sustainable use of its by-products |
| title_full | Bioactive limonoids from Carapa guianensis seeds oil and the sustainable use of its by-products |
| title_fullStr | Bioactive limonoids from Carapa guianensis seeds oil and the sustainable use of its by-products |
| title_full_unstemmed | Bioactive limonoids from Carapa guianensis seeds oil and the sustainable use of its by-products |
| title_short | Bioactive limonoids from Carapa guianensis seeds oil and the sustainable use of its by-products |
| title_sort | bioactive limonoids from carapa guianensis seeds oil and the sustainable use of its by products |
| topic | Andiroba Meliaceae Insecticide Medicinal Plant |
| url | http://www.sciencedirect.com/science/article/pii/S2666027X23000026 |
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