Antigen Presenting Cells Link the Female Genital Tract Microbiome to Mucosal Inflammation, With Hormonal Contraception as an Additional Modulator of Inflammatory Signatures

Antigen Presenting Cells Link the Female Genital Tract Microbiome to Mucosal Inflammation, With Hormonal Contraception as an Additional Modulator of Inflammatory Signatures

The microbiome of the female genital tract (FGT) is closely linked to reproductive health outcomes. Diverse, anaerobe-dominated communities with low Lactobacillus abundance are associated with a number of adverse reproductive outcomes, such as preterm birth, cervical dysplasia, and sexually transmit...

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Bibliographic Details
Main Authors: Elizabeth H. Byrne, Mara Farcasanu, Seth M. Bloom, Nondumiso Xulu, Jiawu Xu, Barry L. Hykes, Nomfuneko A. Mafunda, Matthew R. Hayward, Mary Dong, Krista L. Dong, Thandeka Gumbi, Fransisca Xolisile Ceasar, Nasreen Ismail, Thumbi Ndung’u, Christina Gosmann, Musie S. Ghebremichael, Scott A. Handley, Caroline M. Mitchell, Alexandra-Chloé Villani, Douglas S. Kwon
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
HIV
female genital tract
microbiome
inflammation
mucosal immunology
hormonal contraception
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.733619/full

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