Revisiting Proteasome Inhibitors: Molecular Underpinnings of Their Development, Mechanisms of Resistance and Strategies to Overcome Anti-Cancer Drug Resistance

Revisiting Proteasome Inhibitors: Molecular Underpinnings of Their Development, Mechanisms of Resistance and Strategies to Overcome Anti-Cancer Drug Resistance

Proteasome inhibitors have shown relevant clinical activity in several hematological malignancies, namely in multiple myeloma and mantle cell lymphoma, improving patient outcomes such as survival and quality of life, when compared with other therapies. However, initial response to the therapy is a c...

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Bibliographic Details
Main Authors: Carlota Leonardo-Sousa, Andreia Neves Carvalho, Romina A. Guedes, Pedro M. P. Fernandes, Natália Aniceto, Jorge A. R. Salvador, Maria João Gama, Rita C. Guedes
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Molecules
Subjects:
ubiquitin–proteasome pathway
proteasome inhibitors
mechanisms of resistance
innate resistance
acquired resistance
multiple myeloma
Online Access:https://www.mdpi.com/1420-3049/27/7/2201

Internet

https://www.mdpi.com/1420-3049/27/7/2201

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