Potential mechanisms of some selected heavy metals in the induction of inflammation and autoimmunity
Inflammation is a physiological event that protects tissues from infection and injury. Chronic inflammation causes immune cell over activation and sustained release of inflammatory cytokines and chemokines cause pathologic conditions including autoimmune diseases. Heavy metals exposure affects innat...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-08-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X221122719 |
| _version_ | 1817993198770847744 |
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| author | Abubakar U Anka Abubakar B Usman Abubakar N Kaoje Ramadan M Kabir Aliyu Bala Mandana Kazem Arki Nikoo Hossein-Khannazer Gholamreza Azizi |
| author_facet | Abubakar U Anka Abubakar B Usman Abubakar N Kaoje Ramadan M Kabir Aliyu Bala Mandana Kazem Arki Nikoo Hossein-Khannazer Gholamreza Azizi |
| author_sort | Abubakar U Anka |
| collection | DOAJ |
| description | Inflammation is a physiological event that protects tissues from infection and injury. Chronic inflammation causes immune cell over activation and sustained release of inflammatory cytokines and chemokines cause pathologic conditions including autoimmune diseases. Heavy metals exposure affects innate and adaptive immune systems through triggering inflammatory responses. It seems that extended inflammatory responses could accelerate heavy metal-induced autoimmunity. In the present review we discuss the exposure route and toxicity of Cadmium (Cd), Lead (Pb), Mercury (Hg), Vanadium (V) and Platinum (Pt) and their effects on inflammatory responses by innate and adaptive immune system and autoimmunity. |
| first_indexed | 2024-04-14T01:36:40Z |
| format | Article |
| id | doaj.art-8687abff515042c598e7914816b96bcd |
| institution | Directory Open Access Journal |
| issn | 2058-7392 |
| language | English |
| last_indexed | 2024-04-14T01:36:40Z |
| publishDate | 2022-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-8687abff515042c598e7914816b96bcd2022-12-22T02:19:55ZengSAGE PublishingEuropean Journal of Inflammation2058-73922022-08-012010.1177/1721727X221122719Potential mechanisms of some selected heavy metals in the induction of inflammation and autoimmunityAbubakar U AnkaAbubakar B UsmanAbubakar N KaojeRamadan M KabirAliyu BalaMandana Kazem ArkiNikoo Hossein-KhannazerGholamreza AziziInflammation is a physiological event that protects tissues from infection and injury. Chronic inflammation causes immune cell over activation and sustained release of inflammatory cytokines and chemokines cause pathologic conditions including autoimmune diseases. Heavy metals exposure affects innate and adaptive immune systems through triggering inflammatory responses. It seems that extended inflammatory responses could accelerate heavy metal-induced autoimmunity. In the present review we discuss the exposure route and toxicity of Cadmium (Cd), Lead (Pb), Mercury (Hg), Vanadium (V) and Platinum (Pt) and their effects on inflammatory responses by innate and adaptive immune system and autoimmunity.https://doi.org/10.1177/1721727X221122719 |
| spellingShingle | Abubakar U Anka Abubakar B Usman Abubakar N Kaoje Ramadan M Kabir Aliyu Bala Mandana Kazem Arki Nikoo Hossein-Khannazer Gholamreza Azizi Potential mechanisms of some selected heavy metals in the induction of inflammation and autoimmunity European Journal of Inflammation |
| title | Potential mechanisms of some selected heavy metals in the induction of inflammation and autoimmunity |
| title_full | Potential mechanisms of some selected heavy metals in the induction of inflammation and autoimmunity |
| title_fullStr | Potential mechanisms of some selected heavy metals in the induction of inflammation and autoimmunity |
| title_full_unstemmed | Potential mechanisms of some selected heavy metals in the induction of inflammation and autoimmunity |
| title_short | Potential mechanisms of some selected heavy metals in the induction of inflammation and autoimmunity |
| title_sort | potential mechanisms of some selected heavy metals in the induction of inflammation and autoimmunity |
| url | https://doi.org/10.1177/1721727X221122719 |
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