Supercritical fluid chromatographic chiral separation of potential P2RX7 antagonists containing one, two and three chiral centers

Supercritical fluid chromatographic chiral separation of potential P2RX7 antagonists containing one, two and three chiral centers

Eleven polysaccharide-based chiral stationary phases were screened to separate stereoisomers of six lactam derivatives by supercritical fluid chromatography (SFC). Those molecules are antagonists of the P2×7 receptor with potential anti-inflammatory activity. They present a mixture of either two ena...

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Bibliographic Details
Main Authors:	Naomi KNAVS, Andreea ZUBAŞ, Georgiana APOSTOL, Christophe FURMAN, Adrian Sorin NICA, Bezhan CHANKVETADZE, Alina GHINET, Emmanuelle LIPKA
Format:	Article
Language:	English
Published:	Elsevier 2024-05-01
Series:	Journal of Chromatography Open
Subjects:	Anti-inflammatory compounds Polysaccharides-based stationary phases Separation of stereoisomers Supercritical fluid chromatography Chiral compounds with multiple chiral centers Small-scale preparative separation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772391724000161

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