The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling

The immune checkpoint TIGIT/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K/AKT/mTOR signaling

Abstract Objective The CD155/TIGIT axis has attracted considerable interest as an emerging immune checkpoint with potential applications in cancer immunotherapy. Our research focused on investigating the role of CD155/TIGIT checkpoints in the progression of triple-negative breast cancer (TNBC). Meth...

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Bibliographic Details
Main Authors: Mingyao Huang, Xiaoqin Yu, Qing Wang, Zirong Jiang, Xiaofen Li, Wei Chen, Chuangui Song
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cell Communication and Signaling
Subjects:
Immune checkpoint
CD155/TIGIT
CD8 + T cells
TNBC
Immunotherapy
Online Access:https://doi.org/10.1186/s12964-023-01455-z

Internet

https://doi.org/10.1186/s12964-023-01455-z

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