Molecular insights and therapeutic targets for blood–brain barrier disruption in ischemic stroke: Critical role of matrix metalloproteinases and tissue-type plasminogen activator

Molecular insights and therapeutic targets for blood–brain barrier disruption in ischemic stroke: Critical role of matrix metalloproteinases and tissue-type plasminogen activator

Blood–brain barrier (BBB) disruption, mediated through matrix metalloproteinases (MMPs) and other mechanisms, is a critical event during ischemic stroke. Tissue plasminogen activator (tPA) is the only FDA-approved thrombolytic therapy for acute ischemic stroke, but the efficacy and safety of its the...

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Bibliographic Details
Main Authors: Rong Jin, Guojun Yang, Guohong Li
Format: Article
Language:English
Published: Elsevier 2010-06-01
Series:Neurobiology of Disease
Subjects:
Blood–brain barrier
Neurovascular unit
tPA
MMPs
Ischemic stroke
Signaling pathways
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110000690

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