Attitudes of physicians and patients toward immediate and intraoperative chemotherapy treatment in colon cancer
Introduction: We have shown in a Phase I trial that immediate adjuvant chemotherapy (IAC) during surgical resection and immediately postoperative is safe and feasible in patients with colon cancer (CC). IAC avoids delays in adjuvant treatment and has the potential to improve survival and quality of...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Cancer Treatment and Research Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294224000108 |
| _version_ | 1827325501349298176 |
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| author | Mehraneh D. Jafari Andrea Mesiti Julianna Brouwer Chelsea McKinney Lari B. Wenzel Alessio Pigazzi Jason A. Zell |
| author_facet | Mehraneh D. Jafari Andrea Mesiti Julianna Brouwer Chelsea McKinney Lari B. Wenzel Alessio Pigazzi Jason A. Zell |
| author_sort | Mehraneh D. Jafari |
| collection | DOAJ |
| description | Introduction: We have shown in a Phase I trial that immediate adjuvant chemotherapy (IAC) during surgical resection and immediately postoperative is safe and feasible in patients with colon cancer (CC). IAC avoids delays in adjuvant treatment and has the potential to improve survival and quality of life. We aim to determine patients and providers attitudes toward this novel multidisciplinary treatment approach. Methods: Two web-based surveys were administered to newly diagnosed CC patients, survivors, surgeons and oncologists. Surveys assessed treatment preferences and perceived barriers to IAC. Chi-square tests were conducted to compare differences between patients’ and providers’ responses. Results: Responses were collected from 35 patients and 40 providers. Patients were more willing to: (1) proceed with IAC to finish treatment earlier thus possibly improving quality of life (p = 0.001); (2) proceed with IAC despite potential side effects (p < 0.001); and (3) proceed with a dose of intraoperative chemotherapy even if on final pathology, may not have been needed (p = 0.002). Patients were more likely to indicate no barriers to collaborative care (p = 0.001) while providers were more likely to cite that it is time consuming, thus a barrier to participation (p = 0.001), has scheduling challenges (p = 0.001), and physicians are not available to participate (p = 0.003). Conclusions: We observed a discordance between what providers and patients value in perioperative and adjuvant CC treatment. Patients are willing to accept IAC despite potential side effects and without survival benefit, highlighting the importance of understanding patient preference. |
| first_indexed | 2024-03-07T14:28:08Z |
| format | Article |
| id | doaj.art-8691f3f1395941a6b3cbde1f53c8076d |
| institution | Directory Open Access Journal |
| issn | 2468-2942 |
| language | English |
| last_indexed | 2024-03-07T14:28:08Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj.art-8691f3f1395941a6b3cbde1f53c8076d2024-03-06T05:28:30ZengElsevierCancer Treatment and Research Communications2468-29422024-01-0139100798Attitudes of physicians and patients toward immediate and intraoperative chemotherapy treatment in colon cancerMehraneh D. Jafari0Andrea Mesiti1Julianna Brouwer2Chelsea McKinney3Lari B. Wenzel4Alessio Pigazzi5Jason A. Zell6Weill Cornell Medical College, Surgery, 525 E 68th Street, K802, New York, NY 10065, United States; Department of Surgery, University of California, Irvine, United StatesWeill Cornell Medical College, Surgery, 525 E 68th Street, K802, New York, NY 10065, United States; Corresponding author.Weill Cornell Medical College, Surgery, 525 E 68th Street, K802, New York, NY 10065, United StatesChao Family Comprehensive Cancer Center, UC Irvine Medical Center, 101 The City Drive South, Orange, CA 92868, United StatesDepartment of Medicine, UC Irvine, United States; Chao Family Comprehensive Cancer Center, UC Irvine Medical Center, 101 The City Drive South, Orange, CA 92868, United StatesWeill Cornell Medical College, Surgery, 525 E 68th Street, K802, New York, NY 10065, United StatesDepartment of Medicine, UC Irvine, United StatesIntroduction: We have shown in a Phase I trial that immediate adjuvant chemotherapy (IAC) during surgical resection and immediately postoperative is safe and feasible in patients with colon cancer (CC). IAC avoids delays in adjuvant treatment and has the potential to improve survival and quality of life. We aim to determine patients and providers attitudes toward this novel multidisciplinary treatment approach. Methods: Two web-based surveys were administered to newly diagnosed CC patients, survivors, surgeons and oncologists. Surveys assessed treatment preferences and perceived barriers to IAC. Chi-square tests were conducted to compare differences between patients’ and providers’ responses. Results: Responses were collected from 35 patients and 40 providers. Patients were more willing to: (1) proceed with IAC to finish treatment earlier thus possibly improving quality of life (p = 0.001); (2) proceed with IAC despite potential side effects (p < 0.001); and (3) proceed with a dose of intraoperative chemotherapy even if on final pathology, may not have been needed (p = 0.002). Patients were more likely to indicate no barriers to collaborative care (p = 0.001) while providers were more likely to cite that it is time consuming, thus a barrier to participation (p = 0.001), has scheduling challenges (p = 0.001), and physicians are not available to participate (p = 0.003). Conclusions: We observed a discordance between what providers and patients value in perioperative and adjuvant CC treatment. Patients are willing to accept IAC despite potential side effects and without survival benefit, highlighting the importance of understanding patient preference.http://www.sciencedirect.com/science/article/pii/S2468294224000108Colon cancerAdjuvant chemotherapyQuality of lifePatient preferencesProvider preferences |
| spellingShingle | Mehraneh D. Jafari Andrea Mesiti Julianna Brouwer Chelsea McKinney Lari B. Wenzel Alessio Pigazzi Jason A. Zell Attitudes of physicians and patients toward immediate and intraoperative chemotherapy treatment in colon cancer Cancer Treatment and Research Communications Colon cancer Adjuvant chemotherapy Quality of life Patient preferences Provider preferences |
| title | Attitudes of physicians and patients toward immediate and intraoperative chemotherapy treatment in colon cancer |
| title_full | Attitudes of physicians and patients toward immediate and intraoperative chemotherapy treatment in colon cancer |
| title_fullStr | Attitudes of physicians and patients toward immediate and intraoperative chemotherapy treatment in colon cancer |
| title_full_unstemmed | Attitudes of physicians and patients toward immediate and intraoperative chemotherapy treatment in colon cancer |
| title_short | Attitudes of physicians and patients toward immediate and intraoperative chemotherapy treatment in colon cancer |
| title_sort | attitudes of physicians and patients toward immediate and intraoperative chemotherapy treatment in colon cancer |
| topic | Colon cancer Adjuvant chemotherapy Quality of life Patient preferences Provider preferences |
| url | http://www.sciencedirect.com/science/article/pii/S2468294224000108 |
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