PI3Kδ activates E2F1 synthesis in response to mRNA translation stress
The oncogenic activity of EBNA1 protein is unknown; it contains a glycine and alanine repeat sequence (GAr) which regulates its own translation in cis. Here the authors show that GAr stimulates PI3Kδ-mediated induction of E2F1 translation, leading to c-Myc induction and stimulation of proliferation....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02282-w |
| _version_ | 1818571076113793024 |
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| author | Sivakumar Vadivel Gnanasundram Slovénie Pyndiah Chrysoula Daskalogianni Kate Armfield Karin Nylander Joanna B. Wilson Robin Fåhraeus |
| author_facet | Sivakumar Vadivel Gnanasundram Slovénie Pyndiah Chrysoula Daskalogianni Kate Armfield Karin Nylander Joanna B. Wilson Robin Fåhraeus |
| author_sort | Sivakumar Vadivel Gnanasundram |
| collection | DOAJ |
| description | The oncogenic activity of EBNA1 protein is unknown; it contains a glycine and alanine repeat sequence (GAr) which regulates its own translation in cis. Here the authors show that GAr stimulates PI3Kδ-mediated induction of E2F1 translation, leading to c-Myc induction and stimulation of proliferation. |
| first_indexed | 2024-12-14T13:50:43Z |
| format | Article |
| id | doaj.art-869477af35b34d6ba3566d32e1799f29 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:50:43Z |
| publishDate | 2017-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-869477af35b34d6ba3566d32e1799f292022-12-21T22:59:05ZengNature PortfolioNature Communications2041-17232017-12-018111010.1038/s41467-017-02282-wPI3Kδ activates E2F1 synthesis in response to mRNA translation stressSivakumar Vadivel Gnanasundram0Slovénie Pyndiah1Chrysoula Daskalogianni2Kate Armfield3Karin Nylander4Joanna B. Wilson5Robin Fåhraeus6Inserm UMRS1162, Equipe Labellisée la Ligue Contre le Cancer, Institut de Génétique Moléculaire, Université Paris 7, Hôpital St. LouisInserm UMRS1162, Equipe Labellisée la Ligue Contre le Cancer, Institut de Génétique Moléculaire, Université Paris 7, Hôpital St. LouisInserm UMRS1162, Equipe Labellisée la Ligue Contre le Cancer, Institut de Génétique Moléculaire, Université Paris 7, Hôpital St. LouisSchool of Life Sciences, College of Medical, Veterinary and Life Sciences, University of GlasgowDepartment of Medical Biosciences, Umeå UniversitySchool of Life Sciences, College of Medical, Veterinary and Life Sciences, University of GlasgowInserm UMRS1162, Equipe Labellisée la Ligue Contre le Cancer, Institut de Génétique Moléculaire, Université Paris 7, Hôpital St. LouisThe oncogenic activity of EBNA1 protein is unknown; it contains a glycine and alanine repeat sequence (GAr) which regulates its own translation in cis. Here the authors show that GAr stimulates PI3Kδ-mediated induction of E2F1 translation, leading to c-Myc induction and stimulation of proliferation.https://doi.org/10.1038/s41467-017-02282-w |
| spellingShingle | Sivakumar Vadivel Gnanasundram Slovénie Pyndiah Chrysoula Daskalogianni Kate Armfield Karin Nylander Joanna B. Wilson Robin Fåhraeus PI3Kδ activates E2F1 synthesis in response to mRNA translation stress Nature Communications |
| title | PI3Kδ activates E2F1 synthesis in response to mRNA translation stress |
| title_full | PI3Kδ activates E2F1 synthesis in response to mRNA translation stress |
| title_fullStr | PI3Kδ activates E2F1 synthesis in response to mRNA translation stress |
| title_full_unstemmed | PI3Kδ activates E2F1 synthesis in response to mRNA translation stress |
| title_short | PI3Kδ activates E2F1 synthesis in response to mRNA translation stress |
| title_sort | pi3kδ activates e2f1 synthesis in response to mrna translation stress |
| url | https://doi.org/10.1038/s41467-017-02282-w |
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