Discovery, characterization, and redesign of potent antimicrobial thanatin orthologs from Chinavia ubica and Murgantia histrionica targeting E. coli LptA

Discovery, characterization, and redesign of potent antimicrobial thanatin orthologs from Chinavia ubica and Murgantia histrionica targeting E. coli LptA

Podisus maculiventris thanatin has been reported as a potent antimicrobial peptide with antibacterial and antifungal activity. Its antibiotic activity has been most thoroughly characterized against E. coli and shown to interfere with multiple pathways, such as the lipopolysaccharide transport (LPT)...

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Bibliographic Details
Main Authors: Kelly Huynh, Amanuel Kibrom, Bruce R. Donald, Pei Zhou
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Journal of Structural Biology: X
Subjects:
Thanatin
LptA
Antimicrobial peptide
Genome mining
Lpt pathway inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S2590152423000077

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