Synergistic Activity of Repurposed Peptide Drug Glatiramer Acetate with Tobramycin against Cystic Fibrosis Pseudomonas aeruginosa

Synergistic Activity of Repurposed Peptide Drug Glatiramer Acetate with Tobramycin against Cystic Fibrosis Pseudomonas aeruginosa

ABSTRACT Pseudomonas aeruginosa is the most common pathogen infecting the lungs of people with cystic fibrosis (CF), causing both acute and chronic infections. Intrinsic and acquired antibiotic resistance, coupled with the physical barriers resulting from desiccated CF sputum, allow P. aeruginosa to...

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Bibliographic Details
Main Authors: Ronan A. Murphy, Matthew Coates, Sophia Thrane, Akshay Sabnis, James Harrison, Silke Schelenz, Andrew M. Edwards, Thomas Vorup-Jensen, Jane C. Davies
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:Microbiology Spectrum
Subjects:
Pseudomonas aeruginosa
antibiotic resistance
antibiotic resistance breaker
antimicrobial peptides
cystic fibrosis
drug repurposing
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00813-22

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