Prevalence of dementia in a level 4 university epilepsy center: how big is the problem?
BackgroundThe relationship between epilepsy and dementia is currently a topic of great interest. Our study aimed to determine the prevalence of dementia diagnoses among patients of a large level 4 university epilepsy center.MethodsIn this retrospective monocentric study conducted at the Department o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1217594/full |
| _version_ | 1797654431337021440 |
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| author | Christoph Helmstaedter Teresa Lutz Vinzent Wolf Juri-Alexander Witt |
| author_facet | Christoph Helmstaedter Teresa Lutz Vinzent Wolf Juri-Alexander Witt |
| author_sort | Christoph Helmstaedter |
| collection | DOAJ |
| description | BackgroundThe relationship between epilepsy and dementia is currently a topic of great interest. Our study aimed to determine the prevalence of dementia diagnoses among patients of a large level 4 university epilepsy center.MethodsIn this retrospective monocentric study conducted at the Department of Epileptology of the University Hospital Bonn, we searched for dementia-related terms in a total of 145,501 medical letters from 40,360 adult patients who were seen between 2003 and 2021. Files with at least one hit were selected and analyzed with regard to diagnoses, age, age at epilepsy onset, and the question as to whether epilepsy preceded or followed the dementia diagnosis.ResultsAmong the medical letters of 513 patients, dementia-related terms were found. The letters of 12.7% of these patients stated a dementia diagnosis, 6.6% were suspected of having dementia, 4.9% had mild cognitive impairment, and 6.6% had other neurodegenerative diseases without dementia. Taking all 40,360 patients into account, the prevalence of diagnosed or suspected dementia was 0.25%. An older age (≥60 years) and late-onset epilepsy (≥60 years), but not a longer epilepsy duration, increased the odds of dementia by 6.1 (CI 3.5–10.7) and 2.9 (CI 1.7–4.7), respectively. Additionally, vascular, metabolic, inflammatory, and behavioral mood-related comorbidities were commonly observed. Epilepsy tended to precede (23.2%) rather than follow (8.1%) the dementia diagnosis.ConclusionDespite the clear limitations of a selection bias and the potential underdiagnosis of dementia and underestimation of its prevalence when relying on the medical letters from a specialized center which rather focuses on epilepsy-related issues, the findings of this study offer valuable insights from the perspective of an epilepsy center. In this setting, the prevalence of dementia in epilepsy is rather low. However, physicians should be aware that the risk of dementia is higher in the elderly, in late-onset epilepsies, and when comorbid risk factors exist. Seizures can also be an early sign of a neurodegenerative disease. Future research should explicitly screen for dementia in patients with epilepsy and stratify them according to their underlying pathologies and comorbidities. |
| first_indexed | 2024-03-11T16:59:26Z |
| format | Article |
| id | doaj.art-869774ef4c024f06bcb169b36324141b |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-11T16:59:26Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-869774ef4c024f06bcb169b36324141b2023-10-20T12:52:39ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-10-011410.3389/fneur.2023.12175941217594Prevalence of dementia in a level 4 university epilepsy center: how big is the problem?Christoph HelmstaedterTeresa LutzVinzent WolfJuri-Alexander WittBackgroundThe relationship between epilepsy and dementia is currently a topic of great interest. Our study aimed to determine the prevalence of dementia diagnoses among patients of a large level 4 university epilepsy center.MethodsIn this retrospective monocentric study conducted at the Department of Epileptology of the University Hospital Bonn, we searched for dementia-related terms in a total of 145,501 medical letters from 40,360 adult patients who were seen between 2003 and 2021. Files with at least one hit were selected and analyzed with regard to diagnoses, age, age at epilepsy onset, and the question as to whether epilepsy preceded or followed the dementia diagnosis.ResultsAmong the medical letters of 513 patients, dementia-related terms were found. The letters of 12.7% of these patients stated a dementia diagnosis, 6.6% were suspected of having dementia, 4.9% had mild cognitive impairment, and 6.6% had other neurodegenerative diseases without dementia. Taking all 40,360 patients into account, the prevalence of diagnosed or suspected dementia was 0.25%. An older age (≥60 years) and late-onset epilepsy (≥60 years), but not a longer epilepsy duration, increased the odds of dementia by 6.1 (CI 3.5–10.7) and 2.9 (CI 1.7–4.7), respectively. Additionally, vascular, metabolic, inflammatory, and behavioral mood-related comorbidities were commonly observed. Epilepsy tended to precede (23.2%) rather than follow (8.1%) the dementia diagnosis.ConclusionDespite the clear limitations of a selection bias and the potential underdiagnosis of dementia and underestimation of its prevalence when relying on the medical letters from a specialized center which rather focuses on epilepsy-related issues, the findings of this study offer valuable insights from the perspective of an epilepsy center. In this setting, the prevalence of dementia in epilepsy is rather low. However, physicians should be aware that the risk of dementia is higher in the elderly, in late-onset epilepsies, and when comorbid risk factors exist. Seizures can also be an early sign of a neurodegenerative disease. Future research should explicitly screen for dementia in patients with epilepsy and stratify them according to their underlying pathologies and comorbidities.https://www.frontiersin.org/articles/10.3389/fneur.2023.1217594/fullepileptologyepilepsyseizuresdementiacognitionneurodegeneration |
| spellingShingle | Christoph Helmstaedter Teresa Lutz Vinzent Wolf Juri-Alexander Witt Prevalence of dementia in a level 4 university epilepsy center: how big is the problem? Frontiers in Neurology epileptology epilepsy seizures dementia cognition neurodegeneration |
| title | Prevalence of dementia in a level 4 university epilepsy center: how big is the problem? |
| title_full | Prevalence of dementia in a level 4 university epilepsy center: how big is the problem? |
| title_fullStr | Prevalence of dementia in a level 4 university epilepsy center: how big is the problem? |
| title_full_unstemmed | Prevalence of dementia in a level 4 university epilepsy center: how big is the problem? |
| title_short | Prevalence of dementia in a level 4 university epilepsy center: how big is the problem? |
| title_sort | prevalence of dementia in a level 4 university epilepsy center how big is the problem |
| topic | epileptology epilepsy seizures dementia cognition neurodegeneration |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1217594/full |
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