Aggregation of Vascular Risk Factors Modulates the Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment Patients
Background: Several vascular risk factors, including hypertension, diabetes, body mass index, and smoking status are found to be associated with cognitive decline and the risk of Alzheimer's disease (AD). We aimed to investigate whether an aggregation of vascular risk factors modulates the ampl...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2020.604246/full |
| _version_ | 1829143073532149760 |
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| author | Liying Zhuang Liying Zhuang Huafu Ni Huafu Ni Junyang Wang Xiaoyan Liu Yajie Lin Yujie Su Kan Zhang Yaguo Li Guoping Peng Benyan Luo |
| author_facet | Liying Zhuang Liying Zhuang Huafu Ni Huafu Ni Junyang Wang Xiaoyan Liu Yajie Lin Yujie Su Kan Zhang Yaguo Li Guoping Peng Benyan Luo |
| author_sort | Liying Zhuang |
| collection | DOAJ |
| description | Background: Several vascular risk factors, including hypertension, diabetes, body mass index, and smoking status are found to be associated with cognitive decline and the risk of Alzheimer's disease (AD). We aimed to investigate whether an aggregation of vascular risk factors modulates the amplitude of low-frequency fluctuation (ALFF) in patients with mild cognitive impairment (MCI).Methods: Forty-three MCI patients and twenty-nine healthy controls (HCs) underwent resting-state functional MRI scans, and spontaneous brain activity was measured by the ALFF technique. The vascular risk profile was represented with the Framingham Heart Study general cardiovascular disease (FHS-CVD) risk score, and each group was further divided into high and low risk subgroups. Two-way ANOVA was performed to explore the main effects of diagnosis and vascular risk and their interaction on ALFF.Results: The main effect of diagnosis on ALFF was found in left middle temporal gyrus (LMTG) and left superior parietal gyrus (LSPG), and the main effect of risk on ALFF was detected in left fusiform gyrus (LFFG), left precuneus (LPCUN), and left cerebellum posterior lobe (LCPL). Patients with MCI exhibited increased ALFF in the LMTG and LSPG than HCs, and participants with high vascular risk showed increased ALFF in the LFFG and LCPL, while decreased ALFF in the LPCUN. An interaction between diagnosis (MCI vs. HC) and FHS-CVD risk (high vs. low) regarding ALFF was observed in the left hippocampus (LHIP). HCs with high vascular risk showed significantly increased ALFF in the LHIP than those with low vascular risk, while MCI patients with high vascular risk showed decreased ALFF in the LHIP than HCs with high vascular risk. Interestingly, the mean ALFF of LHIP positively correlated with word recall test in HCs with high vascular risk (rho = 0.630, P = 0.016), while negatively correlated with the same test in MCI patients with high vascular risk (rho = −0.607, P = 0.001).Conclusions: This study provides preliminary evidence highlighting that the aggregation of vascular risk factors modulates the spontaneous brain activity in MCI patients, and this may serve as a potential imaging mechanism underlying vascular contribution to AD. |
| first_indexed | 2024-12-14T20:42:49Z |
| format | Article |
| id | doaj.art-8697bc3cc6bf4d3cae11645cab970a31 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-14T20:42:49Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-8697bc3cc6bf4d3cae11645cab970a312022-12-21T22:48:11ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652020-12-011210.3389/fnagi.2020.604246604246Aggregation of Vascular Risk Factors Modulates the Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment PatientsLiying Zhuang0Liying Zhuang1Huafu Ni2Huafu Ni3Junyang Wang4Xiaoyan Liu5Yajie Lin6Yujie Su7Kan Zhang8Yaguo Li9Guoping Peng10Benyan Luo11Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Neurology, Zhejiang Hospital, Hangzhou, ChinaDepartment of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Neurology, Beilun People's Hospital, Ningbo, ChinaDepartment of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Neurology, Zhejiang Hospital, Hangzhou, ChinaDepartment of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaBackground: Several vascular risk factors, including hypertension, diabetes, body mass index, and smoking status are found to be associated with cognitive decline and the risk of Alzheimer's disease (AD). We aimed to investigate whether an aggregation of vascular risk factors modulates the amplitude of low-frequency fluctuation (ALFF) in patients with mild cognitive impairment (MCI).Methods: Forty-three MCI patients and twenty-nine healthy controls (HCs) underwent resting-state functional MRI scans, and spontaneous brain activity was measured by the ALFF technique. The vascular risk profile was represented with the Framingham Heart Study general cardiovascular disease (FHS-CVD) risk score, and each group was further divided into high and low risk subgroups. Two-way ANOVA was performed to explore the main effects of diagnosis and vascular risk and their interaction on ALFF.Results: The main effect of diagnosis on ALFF was found in left middle temporal gyrus (LMTG) and left superior parietal gyrus (LSPG), and the main effect of risk on ALFF was detected in left fusiform gyrus (LFFG), left precuneus (LPCUN), and left cerebellum posterior lobe (LCPL). Patients with MCI exhibited increased ALFF in the LMTG and LSPG than HCs, and participants with high vascular risk showed increased ALFF in the LFFG and LCPL, while decreased ALFF in the LPCUN. An interaction between diagnosis (MCI vs. HC) and FHS-CVD risk (high vs. low) regarding ALFF was observed in the left hippocampus (LHIP). HCs with high vascular risk showed significantly increased ALFF in the LHIP than those with low vascular risk, while MCI patients with high vascular risk showed decreased ALFF in the LHIP than HCs with high vascular risk. Interestingly, the mean ALFF of LHIP positively correlated with word recall test in HCs with high vascular risk (rho = 0.630, P = 0.016), while negatively correlated with the same test in MCI patients with high vascular risk (rho = −0.607, P = 0.001).Conclusions: This study provides preliminary evidence highlighting that the aggregation of vascular risk factors modulates the spontaneous brain activity in MCI patients, and this may serve as a potential imaging mechanism underlying vascular contribution to AD.https://www.frontiersin.org/articles/10.3389/fnagi.2020.604246/fullmild cognitive impairmentfunctional magnetic resonance imagingamplitude of low frequency fluctuationvascular riskcognition |
| spellingShingle | Liying Zhuang Liying Zhuang Huafu Ni Huafu Ni Junyang Wang Xiaoyan Liu Yajie Lin Yujie Su Kan Zhang Yaguo Li Guoping Peng Benyan Luo Aggregation of Vascular Risk Factors Modulates the Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment Patients Frontiers in Aging Neuroscience mild cognitive impairment functional magnetic resonance imaging amplitude of low frequency fluctuation vascular risk cognition |
| title | Aggregation of Vascular Risk Factors Modulates the Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment Patients |
| title_full | Aggregation of Vascular Risk Factors Modulates the Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment Patients |
| title_fullStr | Aggregation of Vascular Risk Factors Modulates the Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment Patients |
| title_full_unstemmed | Aggregation of Vascular Risk Factors Modulates the Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment Patients |
| title_short | Aggregation of Vascular Risk Factors Modulates the Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment Patients |
| title_sort | aggregation of vascular risk factors modulates the amplitude of low frequency fluctuation in mild cognitive impairment patients |
| topic | mild cognitive impairment functional magnetic resonance imaging amplitude of low frequency fluctuation vascular risk cognition |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2020.604246/full |
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