Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
Abstract Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are recognized as foreign materials by the body and stimulate innate immunity, which in turn impacts adaptive immunity. Therefore,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-10-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-023-01086-x |
| _version_ | 1797637054924849152 |
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| author | Yeji Lee Michaela Jeong Jeongeun Park Hyein Jung Hyukjin Lee |
| author_facet | Yeji Lee Michaela Jeong Jeongeun Park Hyein Jung Hyukjin Lee |
| author_sort | Yeji Lee |
| collection | DOAJ |
| description | Abstract Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are recognized as foreign materials by the body and stimulate innate immunity, which in turn impacts adaptive immunity. Therefore, it is crucial to understand the specific type of innate immune response triggered by lipid nanoparticles. This article provides an overview of the immunological response in the body, explores how lipid nanoparticles activate the innate immune system, and examines the adverse effects and immunogenicity-related development pathways associated with these nanoparticles. Finally, we highlight and explore strategies for regulating the immunogenicity of lipid nanoparticles. |
| first_indexed | 2024-03-11T12:43:53Z |
| format | Article |
| id | doaj.art-869834d640d44333b4372064de7d8c73 |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-03-11T12:43:53Z |
| publishDate | 2023-10-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-869834d640d44333b4372064de7d8c732023-11-05T12:08:43ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132023-10-0155102085209610.1038/s12276-023-01086-xImmunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeuticsYeji Lee0Michaela Jeong1Jeongeun Park2Hyein Jung3Hyukjin Lee4College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans UniversityCollege of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans UniversityCollege of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans UniversityCollege of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans UniversityCollege of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans UniversityAbstract Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are recognized as foreign materials by the body and stimulate innate immunity, which in turn impacts adaptive immunity. Therefore, it is crucial to understand the specific type of innate immune response triggered by lipid nanoparticles. This article provides an overview of the immunological response in the body, explores how lipid nanoparticles activate the innate immune system, and examines the adverse effects and immunogenicity-related development pathways associated with these nanoparticles. Finally, we highlight and explore strategies for regulating the immunogenicity of lipid nanoparticles.https://doi.org/10.1038/s12276-023-01086-x |
| spellingShingle | Yeji Lee Michaela Jeong Jeongeun Park Hyein Jung Hyukjin Lee Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics Experimental and Molecular Medicine |
| title | Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics |
| title_full | Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics |
| title_fullStr | Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics |
| title_full_unstemmed | Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics |
| title_short | Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics |
| title_sort | immunogenicity of lipid nanoparticles and its impact on the efficacy of mrna vaccines and therapeutics |
| url | https://doi.org/10.1038/s12276-023-01086-x |
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