Seroprevalence against Diphtheria in Pregnant Women and Newborns in Colombia: New Arguments to Promote Maternal Immunization
The tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine is recommended during pregnancy for neonatal protection against pertussis, although little is known of the protection it provides against diphtheria. The work used a cross-sectional design to estimate seroprevalenc...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/3/458 |
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| author | Laura María Rivera-Santamaría Doracelly Hincapié-Palacio Jesús Ochoa Felipe Vargas-Restrepo Marta C. Ospina Seti Buitrago-Giraldo |
| author_facet | Laura María Rivera-Santamaría Doracelly Hincapié-Palacio Jesús Ochoa Felipe Vargas-Restrepo Marta C. Ospina Seti Buitrago-Giraldo |
| author_sort | Laura María Rivera-Santamaría |
| collection | DOAJ |
| description | The tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine is recommended during pregnancy for neonatal protection against pertussis, although little is known of the protection it provides against diphtheria. The work used a cross-sectional design to estimate seroprevalence against diphtheria in 805 pregnant women with ≥37 gestation weeks and their newborns whose deliveries were attended in eight hospitals randomly chosen from a subregion of Antioquia, Colombia and to explore factors related with maternal protection. Levels of IgG antibodies were determined by using a commercial enzyme-linked immunosorbent assay test. Placental transfer of antibodies and crude and adjusted prevalence ratio (aPR) were analyzed to describe factors related with maternal protection against diphtheria. Protection against diphtheria was observed in 91.7% (95% CI 90.3–93.0) of the pregnant women and 93.1% (95% CI 91.7–94.4) of newborns, whose antibody levels were positively correlated (Spearman’s r = 0.769; <i>p</i> = 0.000). Maternal protection could be influenced by having been vaccinated during the current pregnancy (aPR 0.85, 95% CI: 0.82–0.93). The protective effect of vaccination during pregnancy and the efficiency of maternal antibody transfers were detected. Public health efforts should focus on increasing Tdap vaccination during each pregnancy to protect mothers and newborns against diphtheria. |
| first_indexed | 2024-03-09T12:18:56Z |
| format | Article |
| id | doaj.art-86993c8deb144308badfc0412a140689 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T12:18:56Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-86993c8deb144308badfc0412a1406892023-11-30T22:43:13ZengMDPI AGVaccines2076-393X2022-03-0110345810.3390/vaccines10030458Seroprevalence against Diphtheria in Pregnant Women and Newborns in Colombia: New Arguments to Promote Maternal ImmunizationLaura María Rivera-Santamaría0Doracelly Hincapié-Palacio1Jesús Ochoa2Felipe Vargas-Restrepo3Marta C. Ospina4Seti Buitrago-Giraldo5“Hector Abad Gómez” National Faculty of Public Health, Universidad de Antioquia UdeA, Medellin 050010, Colombia“Hector Abad Gómez” National Faculty of Public Health, Universidad de Antioquia UdeA, Medellin 050010, Colombia“Hector Abad Gómez” National Faculty of Public Health, Universidad de Antioquia UdeA, Medellin 050010, Colombia“Hector Abad Gómez” National Faculty of Public Health, Universidad de Antioquia UdeA, Medellin 050010, ColombiaLaboratory of Public Health of the Regional Secretariat of Health and Social Protection of Antioquia, Medellin 050010, ColombiaLaboratory of Public Health of the Regional Secretariat of Health and Social Protection of Antioquia, Medellin 050010, ColombiaThe tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine is recommended during pregnancy for neonatal protection against pertussis, although little is known of the protection it provides against diphtheria. The work used a cross-sectional design to estimate seroprevalence against diphtheria in 805 pregnant women with ≥37 gestation weeks and their newborns whose deliveries were attended in eight hospitals randomly chosen from a subregion of Antioquia, Colombia and to explore factors related with maternal protection. Levels of IgG antibodies were determined by using a commercial enzyme-linked immunosorbent assay test. Placental transfer of antibodies and crude and adjusted prevalence ratio (aPR) were analyzed to describe factors related with maternal protection against diphtheria. Protection against diphtheria was observed in 91.7% (95% CI 90.3–93.0) of the pregnant women and 93.1% (95% CI 91.7–94.4) of newborns, whose antibody levels were positively correlated (Spearman’s r = 0.769; <i>p</i> = 0.000). Maternal protection could be influenced by having been vaccinated during the current pregnancy (aPR 0.85, 95% CI: 0.82–0.93). The protective effect of vaccination during pregnancy and the efficiency of maternal antibody transfers were detected. Public health efforts should focus on increasing Tdap vaccination during each pregnancy to protect mothers and newborns against diphtheria.https://www.mdpi.com/2076-393X/10/3/458seroepidemiological studiesdiphtheria-tetanus-acellular pertussis vaccinesimmunizationColombia |
| spellingShingle | Laura María Rivera-Santamaría Doracelly Hincapié-Palacio Jesús Ochoa Felipe Vargas-Restrepo Marta C. Ospina Seti Buitrago-Giraldo Seroprevalence against Diphtheria in Pregnant Women and Newborns in Colombia: New Arguments to Promote Maternal Immunization Vaccines seroepidemiological studies diphtheria-tetanus-acellular pertussis vaccines immunization Colombia |
| title | Seroprevalence against Diphtheria in Pregnant Women and Newborns in Colombia: New Arguments to Promote Maternal Immunization |
| title_full | Seroprevalence against Diphtheria in Pregnant Women and Newborns in Colombia: New Arguments to Promote Maternal Immunization |
| title_fullStr | Seroprevalence against Diphtheria in Pregnant Women and Newborns in Colombia: New Arguments to Promote Maternal Immunization |
| title_full_unstemmed | Seroprevalence against Diphtheria in Pregnant Women and Newborns in Colombia: New Arguments to Promote Maternal Immunization |
| title_short | Seroprevalence against Diphtheria in Pregnant Women and Newborns in Colombia: New Arguments to Promote Maternal Immunization |
| title_sort | seroprevalence against diphtheria in pregnant women and newborns in colombia new arguments to promote maternal immunization |
| topic | seroepidemiological studies diphtheria-tetanus-acellular pertussis vaccines immunization Colombia |
| url | https://www.mdpi.com/2076-393X/10/3/458 |
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