Serial macro-architectural alterations with levodopa in Parkinson′s disease: Polysomnography (PSG)-based analysis
Purpose: We studied the sleep macroarchitecture with polysomnography (PSG) in drug naïve patients with Parkinson′s disease (PD) and reassessed them following treatment with levodopa. Materials and Methods: This prospective hospital-based study included 15 patients with PD (age: 59 ± 11.2 years, dura...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2015;volume=18;issue=3;spage=309;epage=313;aulast=Joy |
| _version_ | 1818081315938893824 |
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| author | Sanju P Joy Sanjib Sinha Pramod Kumar Pal Samhita Panda M Philip Arun B Taly |
| author_facet | Sanju P Joy Sanjib Sinha Pramod Kumar Pal Samhita Panda M Philip Arun B Taly |
| author_sort | Sanju P Joy |
| collection | DOAJ |
| description | Purpose: We studied the sleep macroarchitecture with polysomnography (PSG) in drug naïve patients with Parkinson′s disease (PD) and reassessed them following treatment with levodopa. Materials and Methods: This prospective hospital-based study included 15 patients with PD (age: 59 ± 11.2 years, duration of PD: 11.8 ± 12.3 months; and male: female (M:F) = 11:4). They were assessed for demography, phenotype, modified Hoehn and Yahr staging (H & Y); Schwab and England and Activities of Daily Living (S and E ADL) Scale; and Unified PDRating Scale (UPDRS). Sleep was assessed using Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), and National Institute of Mental Health and Neurosciences (NIMHANS) comprehensive sleep disorder questionnaire. They underwent overnight PSG at baseline and after13.3 ± 5.7 months of levodopa (440 mg/day). Results: Patients with PD had responded to levodopa as indicated by the significant improvement in UPDRS motor score in ON state compared to OFF state. Nocturnal sleep quality indices did not vary significantly, but the excessive daytime somnolence improved (P = 0.04) with levodopa. Sleep efficiency (P = 0.65), latency to sleep onset (P = 0.19), latency to stage 1 (P = 0.12), and duration of stage 1 (P = 0.55) had increased. Duration of ′awake in bed′ (P = 0.24), slow wave sleep (P = 0.29), and rapid eye movement (REM) sleep (P = 0.24) decreased with treatment. Periodic leg movements (PLMs) had reduced (P = 0.68) and mean oxygen saturation during sleep improved (P = 0.002). Surprisingly, snore index (P < 0.03) during sleep had increased with levodopa. Conclusions: Sleep alterations in PD occur even in early stages due to the disease process. There was improvement in most of the parameters of sleep macroarchitecture with levodopa. |
| first_indexed | 2024-12-10T19:04:16Z |
| format | Article |
| id | doaj.art-869c8535fe8b4271b2f8645058319ad2 |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-10T19:04:16Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-869c8535fe8b4271b2f8645058319ad22022-12-22T01:36:55ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492015-01-0118330931310.4103/0972-2327.160102Serial macro-architectural alterations with levodopa in Parkinson′s disease: Polysomnography (PSG)-based analysisSanju P JoySanjib SinhaPramod Kumar PalSamhita PandaM PhilipArun B TalyPurpose: We studied the sleep macroarchitecture with polysomnography (PSG) in drug naïve patients with Parkinson′s disease (PD) and reassessed them following treatment with levodopa. Materials and Methods: This prospective hospital-based study included 15 patients with PD (age: 59 ± 11.2 years, duration of PD: 11.8 ± 12.3 months; and male: female (M:F) = 11:4). They were assessed for demography, phenotype, modified Hoehn and Yahr staging (H & Y); Schwab and England and Activities of Daily Living (S and E ADL) Scale; and Unified PDRating Scale (UPDRS). Sleep was assessed using Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), and National Institute of Mental Health and Neurosciences (NIMHANS) comprehensive sleep disorder questionnaire. They underwent overnight PSG at baseline and after13.3 ± 5.7 months of levodopa (440 mg/day). Results: Patients with PD had responded to levodopa as indicated by the significant improvement in UPDRS motor score in ON state compared to OFF state. Nocturnal sleep quality indices did not vary significantly, but the excessive daytime somnolence improved (P = 0.04) with levodopa. Sleep efficiency (P = 0.65), latency to sleep onset (P = 0.19), latency to stage 1 (P = 0.12), and duration of stage 1 (P = 0.55) had increased. Duration of ′awake in bed′ (P = 0.24), slow wave sleep (P = 0.29), and rapid eye movement (REM) sleep (P = 0.24) decreased with treatment. Periodic leg movements (PLMs) had reduced (P = 0.68) and mean oxygen saturation during sleep improved (P = 0.002). Surprisingly, snore index (P < 0.03) during sleep had increased with levodopa. Conclusions: Sleep alterations in PD occur even in early stages due to the disease process. There was improvement in most of the parameters of sleep macroarchitecture with levodopa.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2015;volume=18;issue=3;spage=309;epage=313;aulast=JoyLevodopaParkinson′s diseasepolysomnographysleep |
| spellingShingle | Sanju P Joy Sanjib Sinha Pramod Kumar Pal Samhita Panda M Philip Arun B Taly Serial macro-architectural alterations with levodopa in Parkinson′s disease: Polysomnography (PSG)-based analysis Annals of Indian Academy of Neurology Levodopa Parkinson′s disease polysomnography sleep |
| title | Serial macro-architectural alterations with levodopa in Parkinson′s disease: Polysomnography (PSG)-based analysis |
| title_full | Serial macro-architectural alterations with levodopa in Parkinson′s disease: Polysomnography (PSG)-based analysis |
| title_fullStr | Serial macro-architectural alterations with levodopa in Parkinson′s disease: Polysomnography (PSG)-based analysis |
| title_full_unstemmed | Serial macro-architectural alterations with levodopa in Parkinson′s disease: Polysomnography (PSG)-based analysis |
| title_short | Serial macro-architectural alterations with levodopa in Parkinson′s disease: Polysomnography (PSG)-based analysis |
| title_sort | serial macro architectural alterations with levodopa in parkinson s disease polysomnography psg based analysis |
| topic | Levodopa Parkinson′s disease polysomnography sleep |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2015;volume=18;issue=3;spage=309;epage=313;aulast=Joy |
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