Serum level of Interleukin-8 in subjects with diabetes, diabetes plus oral lichen planus, and oral lichen planus: A biochemical study
Background: Correlation between diabetes mellitus (DM) and oral lichen planus (OLP) seems probable. Since Interleukin-8 (IL-8) is an important inflammatory mediator involved in both conditions, this study aimed to measure and compare the serum level of IL-8 in DM, OLP, and DM + OLP patients in compa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Dental Research Journal |
| Subjects: | |
| Online Access: | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2016;volume=13;issue=5;spage=413;epage=418;aulast=Tavangar |
| _version_ | 1819041102947155968 |
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| author | Atefeh Tavangar Faezeh Khozeimeh Fereshtehossadat Ghoreishian Mahsa Abbasi Boroujeni |
| author_facet | Atefeh Tavangar Faezeh Khozeimeh Fereshtehossadat Ghoreishian Mahsa Abbasi Boroujeni |
| author_sort | Atefeh Tavangar |
| collection | DOAJ |
| description | Background: Correlation between diabetes mellitus (DM) and oral lichen planus (OLP) seems probable. Since Interleukin-8 (IL-8) is an important inflammatory mediator involved in both conditions, this study aimed to measure and compare the serum level of IL-8 in DM, OLP, and DM + OLP patients in comparison with healthy individuals.
Materials and Methods: This cross sectional study was conducted on 75 patients (30 OLP, 5 OLP and type II DM, 20 type II DM, and 20 healthy controls). Serum levels of IL-8, fasting blood sugar (FBS) and 2-h postprandial blood sugar were measured in the four groups. Data were analyzed using SPSS version 20 by one-way ANOVA and post_hocleast significant difference test.
Results: Type II DM patients with OLP had the highest mean serum level of IL-8 followed by OLP, DM and control groups, respectively. Pairwise comparison of groups revealed significant differences in serum IL-8 between the control and OLP and also control and OLP+DM (P < 0.05) groups. No other significant differences were noted. The mean levels of FBS and 2-h postprandial blood sugar were the highest in OLP+DM patients followed by DM, OLP and control groups, respectively.
Conclusion: The ascending trend of serum level of IL-8 in the control, DM, OLP, and DM+OLP patients may indicate the role of this factor in the pathogenesis of DM and OLP. Moreover, it may play a synergistic role in patients suffering from both conditions. |
| first_indexed | 2024-12-21T09:19:40Z |
| format | Article |
| id | doaj.art-869dfe29dfbc4921a728ec4cc13772ab |
| institution | Directory Open Access Journal |
| issn | 1735-3327 2008-0255 |
| language | English |
| last_indexed | 2024-12-21T09:19:40Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dental Research Journal |
| spelling | doaj.art-869dfe29dfbc4921a728ec4cc13772ab2022-12-21T19:09:02ZengWolters Kluwer Medknow PublicationsDental Research Journal1735-33272008-02552016-01-0113541341810.4103/1735-3327.192277Serum level of Interleukin-8 in subjects with diabetes, diabetes plus oral lichen planus, and oral lichen planus: A biochemical studyAtefeh TavangarFaezeh KhozeimehFereshtehossadat GhoreishianMahsa Abbasi BoroujeniBackground: Correlation between diabetes mellitus (DM) and oral lichen planus (OLP) seems probable. Since Interleukin-8 (IL-8) is an important inflammatory mediator involved in both conditions, this study aimed to measure and compare the serum level of IL-8 in DM, OLP, and DM + OLP patients in comparison with healthy individuals. Materials and Methods: This cross sectional study was conducted on 75 patients (30 OLP, 5 OLP and type II DM, 20 type II DM, and 20 healthy controls). Serum levels of IL-8, fasting blood sugar (FBS) and 2-h postprandial blood sugar were measured in the four groups. Data were analyzed using SPSS version 20 by one-way ANOVA and post_hocleast significant difference test. Results: Type II DM patients with OLP had the highest mean serum level of IL-8 followed by OLP, DM and control groups, respectively. Pairwise comparison of groups revealed significant differences in serum IL-8 between the control and OLP and also control and OLP+DM (P < 0.05) groups. No other significant differences were noted. The mean levels of FBS and 2-h postprandial blood sugar were the highest in OLP+DM patients followed by DM, OLP and control groups, respectively. Conclusion: The ascending trend of serum level of IL-8 in the control, DM, OLP, and DM+OLP patients may indicate the role of this factor in the pathogenesis of DM and OLP. Moreover, it may play a synergistic role in patients suffering from both conditions.http://www.drjjournal.net/article.asp?issn=1735-3327;year=2016;volume=13;issue=5;spage=413;epage=418;aulast=Tavangardiabetes mellitusinterleukin-8lichen planusoralserumtype 2 |
| spellingShingle | Atefeh Tavangar Faezeh Khozeimeh Fereshtehossadat Ghoreishian Mahsa Abbasi Boroujeni Serum level of Interleukin-8 in subjects with diabetes, diabetes plus oral lichen planus, and oral lichen planus: A biochemical study Dental Research Journal diabetes mellitus interleukin-8 lichen planus oral serum type 2 |
| title | Serum level of Interleukin-8 in subjects with diabetes, diabetes plus oral lichen planus, and oral lichen planus: A biochemical study |
| title_full | Serum level of Interleukin-8 in subjects with diabetes, diabetes plus oral lichen planus, and oral lichen planus: A biochemical study |
| title_fullStr | Serum level of Interleukin-8 in subjects with diabetes, diabetes plus oral lichen planus, and oral lichen planus: A biochemical study |
| title_full_unstemmed | Serum level of Interleukin-8 in subjects with diabetes, diabetes plus oral lichen planus, and oral lichen planus: A biochemical study |
| title_short | Serum level of Interleukin-8 in subjects with diabetes, diabetes plus oral lichen planus, and oral lichen planus: A biochemical study |
| title_sort | serum level of interleukin 8 in subjects with diabetes diabetes plus oral lichen planus and oral lichen planus a biochemical study |
| topic | diabetes mellitus interleukin-8 lichen planus oral serum type 2 |
| url | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2016;volume=13;issue=5;spage=413;epage=418;aulast=Tavangar |
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