Neuroglobin and cytoglobin: two new members of globin family
The globin family has long been defined by myoglobin and hemoglobin, proteins with the functions of oxygen storage and transportation, respectively. Recently, two new members of this family were discovered: neuroglobin present in neurons and retinal cells and cytoglobin found in various types of tis...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2011-01-01
|
| Series: | Revista Brasileira de Hematologia e Hemoterapia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000400017 |
| _version_ | 1818650188999294976 |
|---|---|
| author | Priscilla Tosqui Marcio Francisco Colombo |
| author_facet | Priscilla Tosqui Marcio Francisco Colombo |
| author_sort | Priscilla Tosqui |
| collection | DOAJ |
| description | The globin family has long been defined by myoglobin and hemoglobin, proteins with the functions of oxygen storage and transportation, respectively. Recently, two new members of this family were discovered: neuroglobin present in neurons and retinal cells and cytoglobin found in various types of tissue. The increased expression of these proteins in hypoxic conditions first suggested a role in oxygen supply. However structural and functional differences, such as the hexacoordinated heme, a high autoxidation rate and different concentrations between different cellular types, have dismissed this hypothesis. The protective role of these globins has already been established. In vitro and in vivo studies have demonstrated increased survival of neurons under stress in the presence of neuroglobin and increased resistance to neurodegenerative diseases. However the mechanism remains unknown. Functions, including detoxification of nitric oxide, free radical scavenging and as an antioxidant and signaling of apoptosis, have also been suggested for neuroglobin and an antifibrotic function for cytoglobin. |
| first_indexed | 2024-12-17T01:46:15Z |
| format | Article |
| id | doaj.art-869e364f84ea43bb835af2831cf25d39 |
| institution | Directory Open Access Journal |
| issn | 1516-8484 1806-0870 |
| language | English |
| last_indexed | 2024-12-17T01:46:15Z |
| publishDate | 2011-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista Brasileira de Hematologia e Hemoterapia |
| spelling | doaj.art-869e364f84ea43bb835af2831cf25d392022-12-21T22:08:11ZengElsevierRevista Brasileira de Hematologia e Hemoterapia1516-84841806-08702011-01-0133430731110.5581/1516-8484.20110082Neuroglobin and cytoglobin: two new members of globin familyPriscilla TosquiMarcio Francisco ColomboThe globin family has long been defined by myoglobin and hemoglobin, proteins with the functions of oxygen storage and transportation, respectively. Recently, two new members of this family were discovered: neuroglobin present in neurons and retinal cells and cytoglobin found in various types of tissue. The increased expression of these proteins in hypoxic conditions first suggested a role in oxygen supply. However structural and functional differences, such as the hexacoordinated heme, a high autoxidation rate and different concentrations between different cellular types, have dismissed this hypothesis. The protective role of these globins has already been established. In vitro and in vivo studies have demonstrated increased survival of neurons under stress in the presence of neuroglobin and increased resistance to neurodegenerative diseases. However the mechanism remains unknown. Functions, including detoxification of nitric oxide, free radical scavenging and as an antioxidant and signaling of apoptosis, have also been suggested for neuroglobin and an antifibrotic function for cytoglobin.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000400017GlobinsHypoxiaNervous system |
| spellingShingle | Priscilla Tosqui Marcio Francisco Colombo Neuroglobin and cytoglobin: two new members of globin family Revista Brasileira de Hematologia e Hemoterapia Globins Hypoxia Nervous system |
| title | Neuroglobin and cytoglobin: two new members of globin family |
| title_full | Neuroglobin and cytoglobin: two new members of globin family |
| title_fullStr | Neuroglobin and cytoglobin: two new members of globin family |
| title_full_unstemmed | Neuroglobin and cytoglobin: two new members of globin family |
| title_short | Neuroglobin and cytoglobin: two new members of globin family |
| title_sort | neuroglobin and cytoglobin two new members of globin family |
| topic | Globins Hypoxia Nervous system |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000400017 |
| work_keys_str_mv | AT priscillatosqui neuroglobinandcytoglobintwonewmembersofglobinfamily AT marciofranciscocolombo neuroglobinandcytoglobintwonewmembersofglobinfamily |