Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis
Cutaneous syncytial myoepithelioma (CSM) is a rare type of cutaneous neoplasm that typically presents as a solitary and well-circumscribed nodule on the skin. It predominantly occurs on the upper and lower extremities of adult patients. Immunohistochemically, CSM is characterized by the co-expressio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Dermatopathology |
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| Online Access: | https://www.mdpi.com/2296-3529/10/3/34 |
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| author | Cesare Ariasi Carola Romanò Iacopo Ghini Gaetano Licata Luca Rubelli Grazia Linda Artelli Piergiacomo Calzavara-Pinton Mariachiara Arisi |
| author_facet | Cesare Ariasi Carola Romanò Iacopo Ghini Gaetano Licata Luca Rubelli Grazia Linda Artelli Piergiacomo Calzavara-Pinton Mariachiara Arisi |
| author_sort | Cesare Ariasi |
| collection | DOAJ |
| description | Cutaneous syncytial myoepithelioma (CSM) is a rare type of cutaneous neoplasm that typically presents as a solitary and well-circumscribed nodule on the skin. It predominantly occurs on the upper and lower extremities of adult patients. Immunohistochemically, CSM is characterized by the co-expression of smooth muscle and epithelial markers. Fluorescence in situ hybridization (FISH) targeting the EWSR1 gene rearrangement is an important diagnostic tool for CSM. In our case report, we found the focal positivity for CD34, which has never been previously observed; this was mostly confined to a central area of the neoplasm. |
| first_indexed | 2024-03-10T22:53:21Z |
| format | Article |
| id | doaj.art-869fbb0d3c6e4215b998eefc79342689 |
| institution | Directory Open Access Journal |
| issn | 2296-3529 |
| language | English |
| last_indexed | 2024-03-10T22:53:21Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dermatopathology |
| spelling | doaj.art-869fbb0d3c6e4215b998eefc793426892023-11-19T10:12:22ZengMDPI AGDermatopathology2296-35292023-08-0110325926510.3390/dermatopathology10030034Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging DiagnosisCesare Ariasi0Carola Romanò1Iacopo Ghini2Gaetano Licata3Luca Rubelli4Grazia Linda Artelli5Piergiacomo Calzavara-Pinton6Mariachiara Arisi7Department of Dermatology, University of Brescia, 25123 Brescia, ItalyDepartment of Dermatology, University of Brescia, 25123 Brescia, ItalyDepartment of Pathology, University of Brescia, 25123 Brescia, ItalyDermatology Unit, San Antonio Abate Hospital, 91016 Trapani, ItalyDepartment of Dermatology, University of Brescia, 25123 Brescia, ItalyDepartment of Dermatology, University of Brescia, 25123 Brescia, ItalyDepartment of Dermatology, University of Brescia, 25123 Brescia, ItalyDepartment of Dermatology, University of Brescia, 25123 Brescia, ItalyCutaneous syncytial myoepithelioma (CSM) is a rare type of cutaneous neoplasm that typically presents as a solitary and well-circumscribed nodule on the skin. It predominantly occurs on the upper and lower extremities of adult patients. Immunohistochemically, CSM is characterized by the co-expression of smooth muscle and epithelial markers. Fluorescence in situ hybridization (FISH) targeting the EWSR1 gene rearrangement is an important diagnostic tool for CSM. In our case report, we found the focal positivity for CD34, which has never been previously observed; this was mostly confined to a central area of the neoplasm.https://www.mdpi.com/2296-3529/10/3/34cutaneous syncytial myoepitheliomaskin neoplasmsEWSR1CD34 |
| spellingShingle | Cesare Ariasi Carola Romanò Iacopo Ghini Gaetano Licata Luca Rubelli Grazia Linda Artelli Piergiacomo Calzavara-Pinton Mariachiara Arisi Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis Dermatopathology cutaneous syncytial myoepithelioma skin neoplasms EWSR1 CD34 |
| title | Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis |
| title_full | Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis |
| title_fullStr | Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis |
| title_full_unstemmed | Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis |
| title_short | Cutaneous Syncytial Myoepithelioma with Positive CD34 Immunohistochemical Staining: An Unusual Tumor and a Challenging Diagnosis |
| title_sort | cutaneous syncytial myoepithelioma with positive cd34 immunohistochemical staining an unusual tumor and a challenging diagnosis |
| topic | cutaneous syncytial myoepithelioma skin neoplasms EWSR1 CD34 |
| url | https://www.mdpi.com/2296-3529/10/3/34 |
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