Non-coding RNAs regulating morphine function: with emphasis on the in vivo and in vitro functions of miR-190
Non-coding RNAs, especially micro-RNAs (miRNAs) have been reported to be involved in a variety of biological processes, including several related to the addictive drugs. The biological functions of opioids, one typical type of addictive drugs, have also been suggested to be regulated by non-coding R...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-06-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00113/full |
| _version_ | 1819260060930408448 |
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| author | Hui eZheng Ping-Yee eLaw Horace H Loh |
| author_facet | Hui eZheng Ping-Yee eLaw Horace H Loh |
| author_sort | Hui eZheng |
| collection | DOAJ |
| description | Non-coding RNAs, especially micro-RNAs (miRNAs) have been reported to be involved in a variety of biological processes, including several related to the addictive drugs. The biological functions of opioids, one typical type of addictive drugs, have also been suggested to be regulated by non-coding RNAs including miRNAs. In the current review, we will examine a variety of mechanisms in which miRNAs could regulate μ-opioid receptor (OPRM1) activities. By using miR-190 as an example, we will demonstrate the critical roles played by miRNAs at the signal cascade from receptor to the systematic responses, including the possible modulations on the adult neurogenesis and in vivo contextual memory. By using miR-23b as an example, we will also examine the direct effects and mechanisms of miRNAs-mediated regulations of opioid receptor levels and how receptor signaling affects the miRNAs’ expression. Finally we will attempt to provide an discussion on the relationship and interaction between various non-coding RNAs and opioids’ functions. |
| first_indexed | 2024-12-23T19:19:54Z |
| format | Article |
| id | doaj.art-869fd3968ab94f17aa3499c75a8e4eef |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-23T19:19:54Z |
| publishDate | 2012-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-869fd3968ab94f17aa3499c75a8e4eef2022-12-21T17:34:13ZengFrontiers Media S.A.Frontiers in Genetics1664-80212012-06-01310.3389/fgene.2012.0011323648Non-coding RNAs regulating morphine function: with emphasis on the in vivo and in vitro functions of miR-190Hui eZheng0Ping-Yee eLaw1Horace H Loh2Guangzhou Institutes of Biomedicine and Health, Chinese Academic of SciencesUniversity of MinnesotaUniversity of MinnesotaNon-coding RNAs, especially micro-RNAs (miRNAs) have been reported to be involved in a variety of biological processes, including several related to the addictive drugs. The biological functions of opioids, one typical type of addictive drugs, have also been suggested to be regulated by non-coding RNAs including miRNAs. In the current review, we will examine a variety of mechanisms in which miRNAs could regulate μ-opioid receptor (OPRM1) activities. By using miR-190 as an example, we will demonstrate the critical roles played by miRNAs at the signal cascade from receptor to the systematic responses, including the possible modulations on the adult neurogenesis and in vivo contextual memory. By using miR-23b as an example, we will also examine the direct effects and mechanisms of miRNAs-mediated regulations of opioid receptor levels and how receptor signaling affects the miRNAs’ expression. Finally we will attempt to provide an discussion on the relationship and interaction between various non-coding RNAs and opioids’ functions.http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00113/fullmicroRNAnon-coding RNAmiR-190opioid addiction |
| spellingShingle | Hui eZheng Ping-Yee eLaw Horace H Loh Non-coding RNAs regulating morphine function: with emphasis on the in vivo and in vitro functions of miR-190 Frontiers in Genetics microRNA non-coding RNA miR-190 opioid addiction |
| title | Non-coding RNAs regulating morphine function: with emphasis on the in vivo and in vitro functions of miR-190 |
| title_full | Non-coding RNAs regulating morphine function: with emphasis on the in vivo and in vitro functions of miR-190 |
| title_fullStr | Non-coding RNAs regulating morphine function: with emphasis on the in vivo and in vitro functions of miR-190 |
| title_full_unstemmed | Non-coding RNAs regulating morphine function: with emphasis on the in vivo and in vitro functions of miR-190 |
| title_short | Non-coding RNAs regulating morphine function: with emphasis on the in vivo and in vitro functions of miR-190 |
| title_sort | non coding rnas regulating morphine function with emphasis on the in vivo and in vitro functions of mir 190 |
| topic | microRNA non-coding RNA miR-190 opioid addiction |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00113/full |
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