Aortic valve calcification in the era of non-coding RNAs: The revolution to come in aortic stenosis management?
Aortic valve stenosis remains the most frequent structural heart disease, especially in the elderly. During the last decade, we noticed an important consideration and a huge number of publications related to the medical and surgical treatment of this disease. However, the molecular aspect of this de...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2020-06-01
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| Series: | Non-coding RNA Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054020300160 |
| _version_ | 1797205221632376832 |
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| author | Joseph Nader Laurent Metzinger Pierre Maitrias Thierry Caus Valérie Metzinger-Le Meuth |
| author_facet | Joseph Nader Laurent Metzinger Pierre Maitrias Thierry Caus Valérie Metzinger-Le Meuth |
| author_sort | Joseph Nader |
| collection | DOAJ |
| description | Aortic valve stenosis remains the most frequent structural heart disease, especially in the elderly. During the last decade, we noticed an important consideration and a huge number of publications related to the medical and surgical treatment of this disease. However, the molecular aspect of this degenerative issue has also been more widely studied recently. As evidenced in oncologic but also cardiac research fields, the emergence of microRNAs in the molecular screening and follow-up makes them potential biomarkers in the future, for the diagnosis, follow-up and treatment of aortic stenosis. Herein, we present a review on the implication of microRNAs in the aortic valve disease management. After listing and describing the main miRNAs of interest in the field, we provide an outline to develop miRNAs as innovative biomarkers and innovative therapeutic strategies, and describe a groundbreaking pre-clinical study using inhibitors of miR-34a in a pre-clinical model of aortic valve stenosis. |
| first_indexed | 2024-04-24T08:47:41Z |
| format | Article |
| id | doaj.art-86a0dd00b2d546b3beafacdfd8499ba9 |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-24T08:47:41Z |
| publishDate | 2020-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-86a0dd00b2d546b3beafacdfd8499ba92024-04-16T12:57:24ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402020-06-01524147Aortic valve calcification in the era of non-coding RNAs: The revolution to come in aortic stenosis management?Joseph Nader0Laurent Metzinger1Pierre Maitrias2Thierry Caus3Valérie Metzinger-Le Meuth4Department of Cardiac Surgery, Amiens University Hospital, Amiens, France; Corresponding author. Department of Cardiac Surgery, Amiens University Hospital, Amiens, Av. René Laennec, 80054, Amiens France.HEMATIM EA4666, C.U.R.S, Université de Picardie Jules Verne, 80025, AMIENS Cedex 1, FranceDepartment of Vascular Surgery, Polyclinique Saint Côme, Compiègne, FranceDepartment of Cardiac Surgery, Amiens University Hospital, Amiens, FranceHEMATIM EA4666, C.U.R.S, Université de Picardie Jules Verne, 80025, AMIENS Cedex 1, France; INSERM U1148, Laboratory for Vascular Translational Science (LVTS), UFR SMBH, Université Paris 13-Sorbonne Paris Cité, 93017, BOBIGNY CEDEX, FranceAortic valve stenosis remains the most frequent structural heart disease, especially in the elderly. During the last decade, we noticed an important consideration and a huge number of publications related to the medical and surgical treatment of this disease. However, the molecular aspect of this degenerative issue has also been more widely studied recently. As evidenced in oncologic but also cardiac research fields, the emergence of microRNAs in the molecular screening and follow-up makes them potential biomarkers in the future, for the diagnosis, follow-up and treatment of aortic stenosis. Herein, we present a review on the implication of microRNAs in the aortic valve disease management. After listing and describing the main miRNAs of interest in the field, we provide an outline to develop miRNAs as innovative biomarkers and innovative therapeutic strategies, and describe a groundbreaking pre-clinical study using inhibitors of miR-34a in a pre-clinical model of aortic valve stenosis.http://www.sciencedirect.com/science/article/pii/S2468054020300160Aortic stenosismicroRNATranslational researchBiomarker |
| spellingShingle | Joseph Nader Laurent Metzinger Pierre Maitrias Thierry Caus Valérie Metzinger-Le Meuth Aortic valve calcification in the era of non-coding RNAs: The revolution to come in aortic stenosis management? Non-coding RNA Research Aortic stenosis microRNA Translational research Biomarker |
| title | Aortic valve calcification in the era of non-coding RNAs: The revolution to come in aortic stenosis management? |
| title_full | Aortic valve calcification in the era of non-coding RNAs: The revolution to come in aortic stenosis management? |
| title_fullStr | Aortic valve calcification in the era of non-coding RNAs: The revolution to come in aortic stenosis management? |
| title_full_unstemmed | Aortic valve calcification in the era of non-coding RNAs: The revolution to come in aortic stenosis management? |
| title_short | Aortic valve calcification in the era of non-coding RNAs: The revolution to come in aortic stenosis management? |
| title_sort | aortic valve calcification in the era of non coding rnas the revolution to come in aortic stenosis management |
| topic | Aortic stenosis microRNA Translational research Biomarker |
| url | http://www.sciencedirect.com/science/article/pii/S2468054020300160 |
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