Effect of temperature‐responsive hydrogel on femoral and sciatic nerve blocks using bupivacaine in Beagle dogs
Abstract Objectives To compare the duration of regional anesthesia of the pelvic limb using bupivacaine with and without a temperature‐responsive hydrogel (TRH) in dogs. Methods Under anesthesia using medetomidine (10 μg·kg−1), alfaxalone (2 mg·kg−1), and isoflurane, seven healthy male Beagles recei...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Veterinary Medicine and Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/vms3.1049 |
| _version_ | 1828057475883991040 |
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| author | Jiyoung Kim Dalhae Kim Donghwi Shin Taehoon Sung Suehyung Rhee Minha Kim Changhun Nam Inhyung Lee Won‐Gyun Son |
| author_facet | Jiyoung Kim Dalhae Kim Donghwi Shin Taehoon Sung Suehyung Rhee Minha Kim Changhun Nam Inhyung Lee Won‐Gyun Son |
| author_sort | Jiyoung Kim |
| collection | DOAJ |
| description | Abstract Objectives To compare the duration of regional anesthesia of the pelvic limb using bupivacaine with and without a temperature‐responsive hydrogel (TRH) in dogs. Methods Under anesthesia using medetomidine (10 μg·kg−1), alfaxalone (2 mg·kg−1), and isoflurane, seven healthy male Beagles received four injections of 0.5% bupivacaine (1 mg·kg−1 with 5 μg·ml−1 epinephrine) to block the femoral and sciatic nerves bilaterally via ultrasound with nerve stimulation guidance. Bupivacaine was used on one pelvic limb (Bup treatment), and bupivacaine with TRH was used on the contralateral limb (Bup‐TRH treatment). The nerve block was considered successful upon the absence of responses to pinching the digital pads and mid‐tibial skin of both pelvic limbs with mosquito forceps; the pinch, proprioception, and locomotion tests were performed before (baseline) and at each hour after the nerve block until sensory and motor functions returned to baseline. The effect of TRH on nerve blocks was analyzed using a linear mixed model. Results The duration of the sensory nerve block at the digital pads and mid‐tibial skin was longer with Bup‐TRH (8.0 ± 1.6 h and 10.9 ± 1.6 h, respectively) than with Bup treatment (3.7 ± 2.0 h and 8.0 ± 1.6 h, respectively). Motor block times of proprioception and locomotion were longer with Bup‐TRH (9.3 ± 1.6 and 12.7 ± 1.5 h, respectively) than with Bup treatment (4.6 ± 1.9 and 9.6 ± 1.5 h, respectively). No complications were observed. Clinical significance TRH extended the duration of regional anesthesia of the pelvic limb using bupivacaine. |
| first_indexed | 2024-04-10T21:13:14Z |
| format | Article |
| id | doaj.art-86a1fa83e9ee43c988bce0581591db99 |
| institution | Directory Open Access Journal |
| issn | 2053-1095 |
| language | English |
| last_indexed | 2024-04-10T21:13:14Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine and Science |
| spelling | doaj.art-86a1fa83e9ee43c988bce0581591db992023-01-20T17:53:08ZengWileyVeterinary Medicine and Science2053-10952023-01-0191919710.1002/vms3.1049Effect of temperature‐responsive hydrogel on femoral and sciatic nerve blocks using bupivacaine in Beagle dogsJiyoung Kim0Dalhae Kim1Donghwi Shin2Taehoon Sung3Suehyung Rhee4Minha Kim5Changhun Nam6Inhyung Lee7Won‐Gyun Son8Department of Veterinary Clinical Sciences College of Veterinary Medicine Seoul National University Seoul Republic of KoreaDepartment of Veterinary Clinical Sciences College of Veterinary Medicine Seoul National University Seoul Republic of KoreaDepartment of Veterinary Clinical Sciences College of Veterinary Medicine Seoul National University Seoul Republic of KoreaDepartment of Veterinary Clinical Sciences College of Veterinary Medicine Seoul National University Seoul Republic of KoreaDepartment of Veterinary Clinical Sciences College of Veterinary Medicine Seoul National University Seoul Republic of KoreaDepartment of Veterinary Clinical Sciences College of Veterinary Medicine Seoul National University Seoul Republic of KoreaDepartment of Veterinary Clinical Sciences College of Veterinary Medicine Seoul National University Seoul Republic of KoreaDepartment of Veterinary Clinical Sciences College of Veterinary Medicine Seoul National University Seoul Republic of KoreaDepartment of Veterinary Clinical Sciences College of Veterinary Medicine Seoul National University Seoul Republic of KoreaAbstract Objectives To compare the duration of regional anesthesia of the pelvic limb using bupivacaine with and without a temperature‐responsive hydrogel (TRH) in dogs. Methods Under anesthesia using medetomidine (10 μg·kg−1), alfaxalone (2 mg·kg−1), and isoflurane, seven healthy male Beagles received four injections of 0.5% bupivacaine (1 mg·kg−1 with 5 μg·ml−1 epinephrine) to block the femoral and sciatic nerves bilaterally via ultrasound with nerve stimulation guidance. Bupivacaine was used on one pelvic limb (Bup treatment), and bupivacaine with TRH was used on the contralateral limb (Bup‐TRH treatment). The nerve block was considered successful upon the absence of responses to pinching the digital pads and mid‐tibial skin of both pelvic limbs with mosquito forceps; the pinch, proprioception, and locomotion tests were performed before (baseline) and at each hour after the nerve block until sensory and motor functions returned to baseline. The effect of TRH on nerve blocks was analyzed using a linear mixed model. Results The duration of the sensory nerve block at the digital pads and mid‐tibial skin was longer with Bup‐TRH (8.0 ± 1.6 h and 10.9 ± 1.6 h, respectively) than with Bup treatment (3.7 ± 2.0 h and 8.0 ± 1.6 h, respectively). Motor block times of proprioception and locomotion were longer with Bup‐TRH (9.3 ± 1.6 and 12.7 ± 1.5 h, respectively) than with Bup treatment (4.6 ± 1.9 and 9.6 ± 1.5 h, respectively). No complications were observed. Clinical significance TRH extended the duration of regional anesthesia of the pelvic limb using bupivacaine.https://doi.org/10.1002/vms3.1049caninehydrogelnerve blocknerve stimulatorregional anesthesiaultrasound‐guided |
| spellingShingle | Jiyoung Kim Dalhae Kim Donghwi Shin Taehoon Sung Suehyung Rhee Minha Kim Changhun Nam Inhyung Lee Won‐Gyun Son Effect of temperature‐responsive hydrogel on femoral and sciatic nerve blocks using bupivacaine in Beagle dogs Veterinary Medicine and Science canine hydrogel nerve block nerve stimulator regional anesthesia ultrasound‐guided |
| title | Effect of temperature‐responsive hydrogel on femoral and sciatic nerve blocks using bupivacaine in Beagle dogs |
| title_full | Effect of temperature‐responsive hydrogel on femoral and sciatic nerve blocks using bupivacaine in Beagle dogs |
| title_fullStr | Effect of temperature‐responsive hydrogel on femoral and sciatic nerve blocks using bupivacaine in Beagle dogs |
| title_full_unstemmed | Effect of temperature‐responsive hydrogel on femoral and sciatic nerve blocks using bupivacaine in Beagle dogs |
| title_short | Effect of temperature‐responsive hydrogel on femoral and sciatic nerve blocks using bupivacaine in Beagle dogs |
| title_sort | effect of temperature responsive hydrogel on femoral and sciatic nerve blocks using bupivacaine in beagle dogs |
| topic | canine hydrogel nerve block nerve stimulator regional anesthesia ultrasound‐guided |
| url | https://doi.org/10.1002/vms3.1049 |
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