Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

Innate immune recognition of foreign nucleic acids induces protective interferon responses. Detection of cytosolic DNA triggers downstream immune signaling through activation of cyclic GMP-AMP synthase (cGAS). We report here the crystal structure of human cGAS, revealing an unanticipated zinc-ribbon...

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Bibliographic Details
Main Authors: Philip J. Kranzusch, Amy Si-Ying Lee, James M. Berger, Jennifer A. Doudna
Format: Article
Language:English
Published: Elsevier 2013-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713002258

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