In vitro response of THP-1 derived macrophages to antimicrobially effective PHMB-coated Ti6Al4V alloy implant material with and without contamination with S. epidermidis and P. aeruginosa

In vitro response of THP-1 derived macrophages to antimicrobially effective PHMB-coated Ti6Al4V alloy implant material with and without contamination with S. epidermidis and P. aeruginosa

Abstract Aim Periprosthetic joint infections are a devastating complication after arthroplasty, leading to rejection of the prosthesis. The prevention of septic loosening may be possible by an antimicrobial coating of the implant surface. Poly (hexamethylene) biguanide hydrochloride [PHMB] seems to...

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Bibliographic Details
Main Authors: Paula Zwicker, Thomas Schmidt, Melanie Hornschuh, Holger Lode, Axel Kramer, Gerald Müller
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2022-01-01
Series:Biomaterials Research
Subjects:
Poly (hexamethylene biguanide) hydrochloride (PHMB)
THP-1 macrophages
Ti6Al4V alloy
Implant surface
Cytokine secretion
Online Access:https://doi.org/10.1186/s40824-021-00247-1

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