Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists

Structural insights into neurokinin 3 receptor activation by endogenous and analogue peptide agonists

Abstract Neurokinin 3 receptor (NK3R) is a tachykinin receptor essential for the hypothalamic-pituitary-gonadal axis. The endogenous peptide agonist neurokinin B (NKB) preferentially activates NK3R, while substance P (SP) binds preferentially to NK1R. In addition, the SP analogue senktide more poten...

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Bibliographic Details
Main Authors: Wenjing Sun, Fan Yang, Huanhuan Zhang, Qingning Yuan, Shenglong Ling, Yuanxia Wang, Pei Lv, Zelin Li, Yifan Luo, Dongsheng Liu, Wanchao Yin, Pan Shi, H. Eric Xu, Changlin Tian
Format: Article
Language:English
Published: Nature Publishing Group 2023-06-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-023-00564-w

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