Substance P-driven feed-forward inhibitory activity in the mammalian spinal cord
<p>Abstract</p> <p>In mammals, somatosensory input activates feedback and feed-forward inhibitory circuits within the spinal cord dorsal horn to modulate sensory processing and thereby affecting sensory perception by the brain. Conventionally, feedback and feed-forward inhibitory a...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2005-06-01
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| Series: | Molecular Pain |
| Online Access: | http://www.molecularpain.com/content/1/1/20 |
| _version_ | 1828933010274123776 |
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| author | King Christopher Takeda Daisuke Chen Meng Nakatsuka Terumasa Ling Jennifer Xing Hong Ataka Toyofumi Vierck Charles Yezierski Robert Gu Jianguo G |
| author_facet | King Christopher Takeda Daisuke Chen Meng Nakatsuka Terumasa Ling Jennifer Xing Hong Ataka Toyofumi Vierck Charles Yezierski Robert Gu Jianguo G |
| author_sort | King Christopher |
| collection | DOAJ |
| description | <p>Abstract</p> <p>In mammals, somatosensory input activates feedback and feed-forward inhibitory circuits within the spinal cord dorsal horn to modulate sensory processing and thereby affecting sensory perception by the brain. Conventionally, feedback and feed-forward inhibitory activity evoked by somatosensory input to the dorsal horn is believed to be driven by glutamate, the principle excitatory neurotransmitter in primary afferent fibers. Substance P (SP), the prototypic neuropeptide released from primary afferent fibers to the dorsal horn, is regarded as a pain substance in the mammalian somatosensory system due to its action on nociceptive projection neurons. Here we report that endogenous SP drives a novel form of feed-forward inhibitory activity in the dorsal horn. The SP-driven feed-forward inhibitory activity is long-lasting and has a temporal phase distinct from glutamate-driven feed-forward inhibitory activity. Compromising SP-driven feed-forward inhibitory activity results in behavioral sensitization. Our findings reveal a fundamental role of SP in recruiting inhibitory activity for sensory processing, which may have important therapeutic implications in treating pathological pain conditions using SP receptors as targets.</p> |
| first_indexed | 2024-12-14T01:10:14Z |
| format | Article |
| id | doaj.art-86a6e16efebd41eeb2d53140aecbf95e |
| institution | Directory Open Access Journal |
| issn | 1744-8069 |
| language | English |
| last_indexed | 2024-12-14T01:10:14Z |
| publishDate | 2005-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Pain |
| spelling | doaj.art-86a6e16efebd41eeb2d53140aecbf95e2022-12-21T23:22:46ZengSAGE PublishingMolecular Pain1744-80692005-06-01112010.1186/1744-8069-1-20Substance P-driven feed-forward inhibitory activity in the mammalian spinal cordKing ChristopherTakeda DaisukeChen MengNakatsuka TerumasaLing JenniferXing HongAtaka ToyofumiVierck CharlesYezierski RobertGu Jianguo G<p>Abstract</p> <p>In mammals, somatosensory input activates feedback and feed-forward inhibitory circuits within the spinal cord dorsal horn to modulate sensory processing and thereby affecting sensory perception by the brain. Conventionally, feedback and feed-forward inhibitory activity evoked by somatosensory input to the dorsal horn is believed to be driven by glutamate, the principle excitatory neurotransmitter in primary afferent fibers. Substance P (SP), the prototypic neuropeptide released from primary afferent fibers to the dorsal horn, is regarded as a pain substance in the mammalian somatosensory system due to its action on nociceptive projection neurons. Here we report that endogenous SP drives a novel form of feed-forward inhibitory activity in the dorsal horn. The SP-driven feed-forward inhibitory activity is long-lasting and has a temporal phase distinct from glutamate-driven feed-forward inhibitory activity. Compromising SP-driven feed-forward inhibitory activity results in behavioral sensitization. Our findings reveal a fundamental role of SP in recruiting inhibitory activity for sensory processing, which may have important therapeutic implications in treating pathological pain conditions using SP receptors as targets.</p>http://www.molecularpain.com/content/1/1/20 |
| spellingShingle | King Christopher Takeda Daisuke Chen Meng Nakatsuka Terumasa Ling Jennifer Xing Hong Ataka Toyofumi Vierck Charles Yezierski Robert Gu Jianguo G Substance P-driven feed-forward inhibitory activity in the mammalian spinal cord Molecular Pain |
| title | Substance P-driven feed-forward inhibitory activity in the mammalian spinal cord |
| title_full | Substance P-driven feed-forward inhibitory activity in the mammalian spinal cord |
| title_fullStr | Substance P-driven feed-forward inhibitory activity in the mammalian spinal cord |
| title_full_unstemmed | Substance P-driven feed-forward inhibitory activity in the mammalian spinal cord |
| title_short | Substance P-driven feed-forward inhibitory activity in the mammalian spinal cord |
| title_sort | substance p driven feed forward inhibitory activity in the mammalian spinal cord |
| url | http://www.molecularpain.com/content/1/1/20 |
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