Cytotoxicity of the sesquiterpene lactones neoambrosin and damsin from Ambrosia maritima against multidrug-resistant cancer cells

Cytotoxicity of the sesquiterpene lactones neoambrosin and damsin from Ambrosia maritima against multidrug-resistant cancer cells

Multidrug resistance (MDR) is a prevailing phenomenon leading to chemotherapy treatment failure in cancer patients. In the current study two known cytotoxic pseudoguaianolide sesquiterpene lactones; neombrosin (1) and damsin (2) that circumvent MDR were identified. The two cytotoxic compounds were i...

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Bibliographic Details
Main Authors:	Mohamed eSaeed, Stefan eJacob, Louis eSandjo, Yoshikazu eSugimoto, Hassan eKhalid, Till eOpatz, Eckhard eThines, Thomas eEfferth
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2015-11-01
Series:	Frontiers in Pharmacology
Subjects:	Asteraceae EGFR p53 Targeted chemotherapy SRC inhibition ABC-transporters
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00267/full

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