New role of astrocytes in neuroprotective mechanisms after ischemic stroke
Astrocytes are the most abundant cell subtypes in the central nervous system. Previous studies believed that astrocytes are supporting cells in the brain, which only provide nutrients for neurons. However, recent studies have found that astrocytes have more crucial and complex functions in the brain...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2023-08-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1770352 |
| _version_ | 1797731230761877504 |
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| author | Xiaoyun Xie Jingli Liu |
| author_facet | Xiaoyun Xie Jingli Liu |
| author_sort | Xiaoyun Xie |
| collection | DOAJ |
| description | Astrocytes are the most abundant cell subtypes in the central nervous system. Previous studies believed that astrocytes are supporting cells in the brain, which only provide nutrients for neurons. However, recent studies have found that astrocytes have more crucial and complex functions in the brain, such as neurogenesis, phagocytosis, and ischemic tolerance. After an ischemic stroke, the activated astrocytes can exert neuroprotective or neurotoxic effects through a variety of pathways. In this review, we will discuss the neuroprotective mechanisms of astrocytes in cerebral ischemia, and mainly focus on reactive astrocytosis or glial scar, neurogenesis, phagocytosis, and cerebral ischemic tolerance, for providing new strategies for the clinical treatment of stroke. |
| first_indexed | 2024-03-12T11:55:50Z |
| format | Article |
| id | doaj.art-86aacea48137483ab85732735514a66a |
| institution | Directory Open Access Journal |
| issn | 0004-282X 1678-4227 |
| language | English |
| last_indexed | 2024-03-12T11:55:50Z |
| publishDate | 2023-08-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-86aacea48137483ab85732735514a66a2023-08-30T22:38:18ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria0004-282X1678-42272023-08-01810874875510.1055/s-0043-1770352New role of astrocytes in neuroprotective mechanisms after ischemic strokeXiaoyun Xie0https://orcid.org/0000-0002-7332-591XJingli Liu1https://orcid.org/0000-0002-3886-3456Guangxi Medical University, The First Affiliated Hospital, Department of Neurology, Nanning, Guangxi, China.Guangxi Medical University, The First Affiliated Hospital, Department of Neurology, Nanning, Guangxi, China.Astrocytes are the most abundant cell subtypes in the central nervous system. Previous studies believed that astrocytes are supporting cells in the brain, which only provide nutrients for neurons. However, recent studies have found that astrocytes have more crucial and complex functions in the brain, such as neurogenesis, phagocytosis, and ischemic tolerance. After an ischemic stroke, the activated astrocytes can exert neuroprotective or neurotoxic effects through a variety of pathways. In this review, we will discuss the neuroprotective mechanisms of astrocytes in cerebral ischemia, and mainly focus on reactive astrocytosis or glial scar, neurogenesis, phagocytosis, and cerebral ischemic tolerance, for providing new strategies for the clinical treatment of stroke.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1770352AstrocytesIschemic StrokeNeurogenesisPhagocytosisIschemic PreconditioningNeuroprotective AgentsAstrócitosAVC IsquêmicoNeurogêneseFagocitosePrecondicionamento IsquêmicoFármacos Neuroprotetores |
| spellingShingle | Xiaoyun Xie Jingli Liu New role of astrocytes in neuroprotective mechanisms after ischemic stroke Arquivos de Neuro-Psiquiatria Astrocytes Ischemic Stroke Neurogenesis Phagocytosis Ischemic Preconditioning Neuroprotective Agents Astrócitos AVC Isquêmico Neurogênese Fagocitose Precondicionamento Isquêmico Fármacos Neuroprotetores |
| title | New role of astrocytes in neuroprotective mechanisms after ischemic stroke |
| title_full | New role of astrocytes in neuroprotective mechanisms after ischemic stroke |
| title_fullStr | New role of astrocytes in neuroprotective mechanisms after ischemic stroke |
| title_full_unstemmed | New role of astrocytes in neuroprotective mechanisms after ischemic stroke |
| title_short | New role of astrocytes in neuroprotective mechanisms after ischemic stroke |
| title_sort | new role of astrocytes in neuroprotective mechanisms after ischemic stroke |
| topic | Astrocytes Ischemic Stroke Neurogenesis Phagocytosis Ischemic Preconditioning Neuroprotective Agents Astrócitos AVC Isquêmico Neurogênese Fagocitose Precondicionamento Isquêmico Fármacos Neuroprotetores |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1770352 |
| work_keys_str_mv | AT xiaoyunxie newroleofastrocytesinneuroprotectivemechanismsafterischemicstroke AT jingliliu newroleofastrocytesinneuroprotectivemechanismsafterischemicstroke |