SKINREMS—A New Method for Assessment of the Niacin Skin Flush Test Response in Schizophrenia
Schizophrenia has been considered a disorder linked with faulty lipid homeostasis, and the proposed tool for assessment of these disruptions is the niacin skin flush test. The aims of the study were: 1. Create a new tool to analyze results of the niacin skin flush test more precisely and objectively...
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| Format: | Article |
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MDPI AG
2020-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/6/1848 |
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| author | Hanna Karakula-Juchnowicz Joanna Rog Piotr Wolszczak Kamil Jonak Ewa Stelmach Paweł Krukow |
| author_facet | Hanna Karakula-Juchnowicz Joanna Rog Piotr Wolszczak Kamil Jonak Ewa Stelmach Paweł Krukow |
| author_sort | Hanna Karakula-Juchnowicz |
| collection | DOAJ |
| description | Schizophrenia has been considered a disorder linked with faulty lipid homeostasis, and the proposed tool for assessment of these disruptions is the niacin skin flush test. The aims of the study were: 1. Create a new tool to analyze results of the niacin skin flush test more precisely and objectively. 2. Verify the utility of a self-created tool for differentiating between schizophrenia (SZ; <i>n</i> = 56), bipolar disorder (BD; <i>n</i> = 29) and healthy control (HC; <i>n</i> = 45) individuals. The proposed developed method, based on the Skin Reaction Measurement Computer System (SKINREMS), allows one to evaluate the response to the niacin skin flush test quickly and objectively. SKINREMS showed good accuracy in discriminating SZ from BD (with sensitivity 91% and specificity 72%), and SZ from HC (71% and 66%, respectively), and sufficient but not excellent accuracy in discriminating BD from HC (55% and 54%, respectively). The pathophysiological pathways and features shared by schizophrenia and bipolar disorder may be the reason for difficulties in fully discriminating between these two mental disorders using the niacin challenge test. The management of disruptions in the phospholipid metabolism and the inflammatory process could potentially become an individualized form of therapy in a subgroup of psychiatric patients. |
| first_indexed | 2024-03-10T19:12:13Z |
| format | Article |
| id | doaj.art-86ac6e44200142e4bd51a9ff911e34b4 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T19:12:13Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-86ac6e44200142e4bd51a9ff911e34b42023-11-20T03:44:51ZengMDPI AGJournal of Clinical Medicine2077-03832020-06-0196184810.3390/jcm9061848SKINREMS—A New Method for Assessment of the Niacin Skin Flush Test Response in SchizophreniaHanna Karakula-Juchnowicz0Joanna Rog1Piotr Wolszczak2Kamil Jonak3Ewa Stelmach4Paweł Krukow51st Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, 20-439 Lublin, Poland1st Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, 20-439 Lublin, PolandDepartment of Automation, Faculty of Mechanical Engineering, Lublin University of Technology, 20-618 Lublin, PolandDepartment of Clinical Neuropsychiatry, Medical University of Lublin, 20-439 Lublin, Poland2nd Department of Psychiatry and Psychiatric Rehabilitation, Medical University of Lublin, 20-439 Lublin, PolandDepartment of Clinical Neuropsychiatry, Medical University of Lublin, 20-439 Lublin, PolandSchizophrenia has been considered a disorder linked with faulty lipid homeostasis, and the proposed tool for assessment of these disruptions is the niacin skin flush test. The aims of the study were: 1. Create a new tool to analyze results of the niacin skin flush test more precisely and objectively. 2. Verify the utility of a self-created tool for differentiating between schizophrenia (SZ; <i>n</i> = 56), bipolar disorder (BD; <i>n</i> = 29) and healthy control (HC; <i>n</i> = 45) individuals. The proposed developed method, based on the Skin Reaction Measurement Computer System (SKINREMS), allows one to evaluate the response to the niacin skin flush test quickly and objectively. SKINREMS showed good accuracy in discriminating SZ from BD (with sensitivity 91% and specificity 72%), and SZ from HC (71% and 66%, respectively), and sufficient but not excellent accuracy in discriminating BD from HC (55% and 54%, respectively). The pathophysiological pathways and features shared by schizophrenia and bipolar disorder may be the reason for difficulties in fully discriminating between these two mental disorders using the niacin challenge test. The management of disruptions in the phospholipid metabolism and the inflammatory process could potentially become an individualized form of therapy in a subgroup of psychiatric patients.https://www.mdpi.com/2077-0383/9/6/1848schizophreniabipolar disorderbiomarkerniacinessential fatty acids |
| spellingShingle | Hanna Karakula-Juchnowicz Joanna Rog Piotr Wolszczak Kamil Jonak Ewa Stelmach Paweł Krukow SKINREMS—A New Method for Assessment of the Niacin Skin Flush Test Response in Schizophrenia Journal of Clinical Medicine schizophrenia bipolar disorder biomarker niacin essential fatty acids |
| title | SKINREMS—A New Method for Assessment of the Niacin Skin Flush Test Response in Schizophrenia |
| title_full | SKINREMS—A New Method for Assessment of the Niacin Skin Flush Test Response in Schizophrenia |
| title_fullStr | SKINREMS—A New Method for Assessment of the Niacin Skin Flush Test Response in Schizophrenia |
| title_full_unstemmed | SKINREMS—A New Method for Assessment of the Niacin Skin Flush Test Response in Schizophrenia |
| title_short | SKINREMS—A New Method for Assessment of the Niacin Skin Flush Test Response in Schizophrenia |
| title_sort | skinrems a new method for assessment of the niacin skin flush test response in schizophrenia |
| topic | schizophrenia bipolar disorder biomarker niacin essential fatty acids |
| url | https://www.mdpi.com/2077-0383/9/6/1848 |
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