The Prognostic Value of Liquid Biopsies for Benefit of Salvage Radiotherapy in Relapsed Oligometastatic Prostate Cancer
To assess the prognostic value of “liquid biopsies” for the benefit of salvage RT in oligometastatic prostate cancer relapse, we enrolled 44 patients in the study between the years 2016 and 2020. All the patients were diagnosed as having an oligometastatic prostate cancer relapse on prostate-specifi...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/17/4095 |
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| author | Natalia V. Bogdanova Hoda Radmanesh Dhanya Ramachandran Anne Caroline Knoechelmann Hans Christiansen Thorsten Derlin Christoph Alexander Joachim von Klot Roland Merten Christoph Henkenberens |
| author_facet | Natalia V. Bogdanova Hoda Radmanesh Dhanya Ramachandran Anne Caroline Knoechelmann Hans Christiansen Thorsten Derlin Christoph Alexander Joachim von Klot Roland Merten Christoph Henkenberens |
| author_sort | Natalia V. Bogdanova |
| collection | DOAJ |
| description | To assess the prognostic value of “liquid biopsies” for the benefit of salvage RT in oligometastatic prostate cancer relapse, we enrolled 44 patients in the study between the years 2016 and 2020. All the patients were diagnosed as having an oligometastatic prostate cancer relapse on prostate-specific membrane antigen (PSMA)-targeted PET-CT and underwent irradiation at the Department of Radiotherapy at the Hannover Medical School. Tumor cells and total RNA, enriched from the liquid biopsies of patients, were processed for the subsequent quantification analysis of relative transcript levels in real-time PCR. In total, 54 gene transcripts known or suggested to be associated with prostate cancer or treatment outcome were prioritized for analysis. We found significant correlations between the relative transcript levels of several investigated genes and the Gleason score, PSA (prostate-specific antigen) value, or UICC stage (tumor node metastasis -TNM classification of malignant tumors from <b>U</b>nion for <b>I</b>nternational <b>C</b>ancer <b>C</b>ontrol). Furthermore, a significant association of <i>MTCO2</i>, <i>FOXM1</i>, <i>SREBF1</i>, <i>HOXB7</i>, <i>FDXR,</i> and <i>MTRNR</i> transcript profiles was found with a temporary and/or long-term benefit from RT. Further studies on larger patients cohorts are necessary to prove our preliminary findings for establishing liquid biopsy tests as a predictive examination method prior to salvage RT. |
| first_indexed | 2024-03-10T01:59:56Z |
| format | Article |
| id | doaj.art-86accd31a4054aafaa6d778869e47639 |
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| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T01:59:56Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-86accd31a4054aafaa6d778869e476392023-11-23T12:49:47ZengMDPI AGCancers2072-66942022-08-011417409510.3390/cancers14174095The Prognostic Value of Liquid Biopsies for Benefit of Salvage Radiotherapy in Relapsed Oligometastatic Prostate CancerNatalia V. Bogdanova0Hoda Radmanesh1Dhanya Ramachandran2Anne Caroline Knoechelmann3Hans Christiansen4Thorsten Derlin5Christoph Alexander Joachim von Klot6Roland Merten7Christoph Henkenberens8Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, GermanyDepartment of Radiation Oncology, Hannover Medical School, 30625 Hannover, GermanyGynecology Research Unit, Clinics of Obstetrics and Gynaecology, Hannover Medical School, 30625 Hannover, GermanyDepartment of Radiation Oncology, Hannover Medical School, 30625 Hannover, GermanyDepartment of Radiation Oncology, Hannover Medical School, 30625 Hannover, GermanyDepartment of Nuclear Medicine, Hannover Medical School, 30625 Hannover, GermanyClinic for Urology, Hannover Medical School, 30625 Hannover, GermanyDepartment of Radiation Oncology, Hannover Medical School, 30625 Hannover, GermanyDepartment of Radiation Oncology, Hannover Medical School, 30625 Hannover, GermanyTo assess the prognostic value of “liquid biopsies” for the benefit of salvage RT in oligometastatic prostate cancer relapse, we enrolled 44 patients in the study between the years 2016 and 2020. All the patients were diagnosed as having an oligometastatic prostate cancer relapse on prostate-specific membrane antigen (PSMA)-targeted PET-CT and underwent irradiation at the Department of Radiotherapy at the Hannover Medical School. Tumor cells and total RNA, enriched from the liquid biopsies of patients, were processed for the subsequent quantification analysis of relative transcript levels in real-time PCR. In total, 54 gene transcripts known or suggested to be associated with prostate cancer or treatment outcome were prioritized for analysis. We found significant correlations between the relative transcript levels of several investigated genes and the Gleason score, PSA (prostate-specific antigen) value, or UICC stage (tumor node metastasis -TNM classification of malignant tumors from <b>U</b>nion for <b>I</b>nternational <b>C</b>ancer <b>C</b>ontrol). Furthermore, a significant association of <i>MTCO2</i>, <i>FOXM1</i>, <i>SREBF1</i>, <i>HOXB7</i>, <i>FDXR,</i> and <i>MTRNR</i> transcript profiles was found with a temporary and/or long-term benefit from RT. Further studies on larger patients cohorts are necessary to prove our preliminary findings for establishing liquid biopsy tests as a predictive examination method prior to salvage RT.https://www.mdpi.com/2072-6694/14/17/4095liquid biopsiescirculating tumor cellsoligometastatic prostate cancerPSMA-PETsalvage radiotherapy |
| spellingShingle | Natalia V. Bogdanova Hoda Radmanesh Dhanya Ramachandran Anne Caroline Knoechelmann Hans Christiansen Thorsten Derlin Christoph Alexander Joachim von Klot Roland Merten Christoph Henkenberens The Prognostic Value of Liquid Biopsies for Benefit of Salvage Radiotherapy in Relapsed Oligometastatic Prostate Cancer Cancers liquid biopsies circulating tumor cells oligometastatic prostate cancer PSMA-PET salvage radiotherapy |
| title | The Prognostic Value of Liquid Biopsies for Benefit of Salvage Radiotherapy in Relapsed Oligometastatic Prostate Cancer |
| title_full | The Prognostic Value of Liquid Biopsies for Benefit of Salvage Radiotherapy in Relapsed Oligometastatic Prostate Cancer |
| title_fullStr | The Prognostic Value of Liquid Biopsies for Benefit of Salvage Radiotherapy in Relapsed Oligometastatic Prostate Cancer |
| title_full_unstemmed | The Prognostic Value of Liquid Biopsies for Benefit of Salvage Radiotherapy in Relapsed Oligometastatic Prostate Cancer |
| title_short | The Prognostic Value of Liquid Biopsies for Benefit of Salvage Radiotherapy in Relapsed Oligometastatic Prostate Cancer |
| title_sort | prognostic value of liquid biopsies for benefit of salvage radiotherapy in relapsed oligometastatic prostate cancer |
| topic | liquid biopsies circulating tumor cells oligometastatic prostate cancer PSMA-PET salvage radiotherapy |
| url | https://www.mdpi.com/2072-6694/14/17/4095 |
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