Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study
Abstract The present investigation using Positron Emission Tomography shows how peptide VSAK can reduce the detrimental effects produced by lipopolysaccharides in Dutch dwarf rabbits, used to develop the Systemic Inflammatory Response Syndrome (SIRS). Animals concomitantly treated with lipopolysacch...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-07-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-94224-2 |
| _version_ | 1818401416535867392 |
|---|---|
| author | Ismael Luna-Reyes Eréndira G. Pérez-Hernández Blanca Delgado-Coello Miguel Ángel Ávila-Rodríguez Jaime Mas-Oliva |
| author_facet | Ismael Luna-Reyes Eréndira G. Pérez-Hernández Blanca Delgado-Coello Miguel Ángel Ávila-Rodríguez Jaime Mas-Oliva |
| author_sort | Ismael Luna-Reyes |
| collection | DOAJ |
| description | Abstract The present investigation using Positron Emission Tomography shows how peptide VSAK can reduce the detrimental effects produced by lipopolysaccharides in Dutch dwarf rabbits, used to develop the Systemic Inflammatory Response Syndrome (SIRS). Animals concomitantly treated with lipopolysaccharides (LPS) and peptide VSAK show important protection in the loss of radiolabeled-glucose uptake observed in diverse organs when animals are exclusively treated with LPS. Treatment with peptide VSAK prevented the onset of changes in serum levels of glucose and insulin associated with the establishment of SIRS and the insulin resistance-like syndrome. Treatment with peptide VSAK also allowed an important attenuation in the circulating levels of pro-inflammatory molecules in LPS-treated animals. As a whole, our data suggest that peptide VSAK might be considered as a candidate in the development of new therapeutic possibilities focused on mitigating the harmful effects produced by lipopolysaccharides during the course of SIRS. |
| first_indexed | 2024-12-14T07:52:07Z |
| format | Article |
| id | doaj.art-86adab916c2243f5b60d761a293bf07c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T07:52:07Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-86adab916c2243f5b60d761a293bf07c2022-12-21T23:10:40ZengNature PortfolioScientific Reports2045-23222021-07-0111111310.1038/s41598-021-94224-2Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET studyIsmael Luna-Reyes0Eréndira G. Pérez-Hernández1Blanca Delgado-Coello2Miguel Ángel Ávila-Rodríguez3Jaime Mas-Oliva4Instituto de Fisiología Celular, Universidad Nacional Autónoma de MéxicoInstituto de Fisiología Celular, Universidad Nacional Autónoma de MéxicoInstituto de Fisiología Celular, Universidad Nacional Autónoma de MéxicoFacultad de Medicina, Universidad Nacional Autónoma de MéxicoInstituto de Fisiología Celular, Universidad Nacional Autónoma de MéxicoAbstract The present investigation using Positron Emission Tomography shows how peptide VSAK can reduce the detrimental effects produced by lipopolysaccharides in Dutch dwarf rabbits, used to develop the Systemic Inflammatory Response Syndrome (SIRS). Animals concomitantly treated with lipopolysaccharides (LPS) and peptide VSAK show important protection in the loss of radiolabeled-glucose uptake observed in diverse organs when animals are exclusively treated with LPS. Treatment with peptide VSAK prevented the onset of changes in serum levels of glucose and insulin associated with the establishment of SIRS and the insulin resistance-like syndrome. Treatment with peptide VSAK also allowed an important attenuation in the circulating levels of pro-inflammatory molecules in LPS-treated animals. As a whole, our data suggest that peptide VSAK might be considered as a candidate in the development of new therapeutic possibilities focused on mitigating the harmful effects produced by lipopolysaccharides during the course of SIRS.https://doi.org/10.1038/s41598-021-94224-2 |
| spellingShingle | Ismael Luna-Reyes Eréndira G. Pérez-Hernández Blanca Delgado-Coello Miguel Ángel Ávila-Rodríguez Jaime Mas-Oliva Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study Scientific Reports |
| title | Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study |
| title_full | Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study |
| title_fullStr | Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study |
| title_full_unstemmed | Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study |
| title_short | Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study |
| title_sort | peptide vsak maintains tissue glucose uptake and attenuates pro inflammatory responses caused by lps in an experimental model of the systemic inflammatory response syndrome a pet study |
| url | https://doi.org/10.1038/s41598-021-94224-2 |
| work_keys_str_mv | AT ismaellunareyes peptidevsakmaintainstissueglucoseuptakeandattenuatesproinflammatoryresponsescausedbylpsinanexperimentalmodelofthesystemicinflammatoryresponsesyndromeapetstudy AT erendiragperezhernandez peptidevsakmaintainstissueglucoseuptakeandattenuatesproinflammatoryresponsescausedbylpsinanexperimentalmodelofthesystemicinflammatoryresponsesyndromeapetstudy AT blancadelgadocoello peptidevsakmaintainstissueglucoseuptakeandattenuatesproinflammatoryresponsescausedbylpsinanexperimentalmodelofthesystemicinflammatoryresponsesyndromeapetstudy AT miguelangelavilarodriguez peptidevsakmaintainstissueglucoseuptakeandattenuatesproinflammatoryresponsescausedbylpsinanexperimentalmodelofthesystemicinflammatoryresponsesyndromeapetstudy AT jaimemasoliva peptidevsakmaintainstissueglucoseuptakeandattenuatesproinflammatoryresponsescausedbylpsinanexperimentalmodelofthesystemicinflammatoryresponsesyndromeapetstudy |