Effectiveness of ACE inhibitor ramipril and its combination with hydrochlorothiazide in patients with arterial hypertension and overweight: CHARISMA Study
Aim. To investigate effectiveness and safety of ramipril therapy, with varying administration time, in patients with mild to moderate arterial hypertension (AH) and overweight (OW).Material and methods. The patients were randomized into two groups: Group I (n=29) received ramipril (Hartil®, FGIS, Hu...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2008-04-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1332 |
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| author | I. P. Kolos T. V. Martynyuk A. S. Safaryan D. V. Nebieridze I. E. Chazova |
| author_facet | I. P. Kolos T. V. Martynyuk A. S. Safaryan D. V. Nebieridze I. E. Chazova |
| author_sort | I. P. Kolos |
| collection | DOAJ |
| description | Aim. To investigate effectiveness and safety of ramipril therapy, with varying administration time, in patients with mild to moderate arterial hypertension (AH) and overweight (OW).Material and methods. The patients were randomized into two groups: Group I (n=29) received ramipril (Hartil®, FGIS, Hungary) in the morning (5 mg/d, at 8-10 am) for 4 weeks; Group II(n=39) received the medication in the evening (5 mg/d, 9-11 pm). Four weeks later, in all patients not achieved target blood pressure (BP) levels (<140/90 mm Hg), ramipril dose was increased up to 10 mg/d. If target BP levels were not achieved after 8 weeks, hydrochlorothiazide (12,5 mg/d) was added. The total length of the study was 16 weeks.Results. After 16 weeks of the treatment, BP levels were similar in both groups. According to office BP measurement results, systolic and diastolic BP (SBP, DBP) levels were significantly reduced in Groups I and II (p<0,05). According to 24-hour BP monitoring data, obtained after 8 and 16 weeks, mean SBP and DBP levels significantly decreased in Weeks 8 and 16 for Groups I and II, respectively. Day- and nighttime BP difference was similar in both groups.Conclusion. Regardless of its administration time, ramipril effectively and safely reduced BP and microalbuminuria levels in patients with Stage I-II AH and OW. |
| first_indexed | 2024-04-10T03:39:36Z |
| format | Article |
| id | doaj.art-86af2408ca604701b197e0c5323ba4df |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:39:36Z |
| publishDate | 2008-04-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-86af2408ca604701b197e0c5323ba4df2023-03-13T07:23:15Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252008-04-017265711042Effectiveness of ACE inhibitor ramipril and its combination with hydrochlorothiazide in patients with arterial hypertension and overweight: CHARISMA StudyI. P. Kolos0T. V. Martynyuk1A. S. Safaryan2D. V. Nebieridze3I. E. Chazova4ФГУ Российский кардиологический научно-производственный комплекс РосмедтехнологииФГУ Российский кардиологический научно-производственный комплекс РосмедтехнологииФГУ Государственный научно-исследовательский центр профилактической медицины Росмедтехнологии, г. МоскваФГУ Государственный научно-исследовательский центр профилактической медицины Росмедтехнологии, г. МоскваФГУ Российский кардиологический научно-производственный комплекс РосмедтехнологииAim. To investigate effectiveness and safety of ramipril therapy, with varying administration time, in patients with mild to moderate arterial hypertension (AH) and overweight (OW).Material and methods. The patients were randomized into two groups: Group I (n=29) received ramipril (Hartil®, FGIS, Hungary) in the morning (5 mg/d, at 8-10 am) for 4 weeks; Group II(n=39) received the medication in the evening (5 mg/d, 9-11 pm). Four weeks later, in all patients not achieved target blood pressure (BP) levels (<140/90 mm Hg), ramipril dose was increased up to 10 mg/d. If target BP levels were not achieved after 8 weeks, hydrochlorothiazide (12,5 mg/d) was added. The total length of the study was 16 weeks.Results. After 16 weeks of the treatment, BP levels were similar in both groups. According to office BP measurement results, systolic and diastolic BP (SBP, DBP) levels were significantly reduced in Groups I and II (p<0,05). According to 24-hour BP monitoring data, obtained after 8 and 16 weeks, mean SBP and DBP levels significantly decreased in Weeks 8 and 16 for Groups I and II, respectively. Day- and nighttime BP difference was similar in both groups.Conclusion. Regardless of its administration time, ramipril effectively and safely reduced BP and microalbuminuria levels in patients with Stage I-II AH and OW.https://cardiovascular.elpub.ru/jour/article/view/1332артериальная гипертензияизбыточная масса теларамиприл |
| spellingShingle | I. P. Kolos T. V. Martynyuk A. S. Safaryan D. V. Nebieridze I. E. Chazova Effectiveness of ACE inhibitor ramipril and its combination with hydrochlorothiazide in patients with arterial hypertension and overweight: CHARISMA Study Кардиоваскулярная терапия и профилактика артериальная гипертензия избыточная масса тела рамиприл |
| title | Effectiveness of ACE inhibitor ramipril and its combination with hydrochlorothiazide in patients with arterial hypertension and overweight: CHARISMA Study |
| title_full | Effectiveness of ACE inhibitor ramipril and its combination with hydrochlorothiazide in patients with arterial hypertension and overweight: CHARISMA Study |
| title_fullStr | Effectiveness of ACE inhibitor ramipril and its combination with hydrochlorothiazide in patients with arterial hypertension and overweight: CHARISMA Study |
| title_full_unstemmed | Effectiveness of ACE inhibitor ramipril and its combination with hydrochlorothiazide in patients with arterial hypertension and overweight: CHARISMA Study |
| title_short | Effectiveness of ACE inhibitor ramipril and its combination with hydrochlorothiazide in patients with arterial hypertension and overweight: CHARISMA Study |
| title_sort | effectiveness of ace inhibitor ramipril and its combination with hydrochlorothiazide in patients with arterial hypertension and overweight charisma study |
| topic | артериальная гипертензия избыточная масса тела рамиприл |
| url | https://cardiovascular.elpub.ru/jour/article/view/1332 |
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