Role of Propolis on Oxidative Stress in Fish Brain
Introduction: Cypermethrin causes its neurotoxic effect through voltage-dependent sodium channels and integral protein ATPases in the neuronal membrane. Brain and nerve damage are often associated with low residual level of pesticides. In vitro and in vivo studies have also shown that pesticides cau...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2013-04-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-155&slc_lang=en&sid=1 |
| _version_ | 1797280585595486208 |
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| author | Shapour Kakoolaki Zeliha Selamoglu Talas Oguz Oguz Cakir Osman Ciftci Ilknur Ozdemir |
| author_facet | Shapour Kakoolaki Zeliha Selamoglu Talas Oguz Oguz Cakir Osman Ciftci Ilknur Ozdemir |
| author_sort | Shapour Kakoolaki |
| collection | DOAJ |
| description | Introduction: Cypermethrin causes its neurotoxic effect through voltage-dependent sodium channels and integral protein ATPases in the neuronal membrane. Brain and nerve damage are often associated with low residual level of pesticides. In vitro and in vivo studies have also shown that pesticides cause free radical-mediated tissue damage in brain. Propolis has antioxidant properties. The main chemical classes found in propolis are flavonoids and phenolics. Bioflavonoids are antioxidant molecules that play important roles in scavenging free radicals, which are produced in neurodegenerative diseases and aging. Methods: To determine the protective role of propolis, rainbow trouts were treated with cypermethrin, followed by biochemical analyses of brain tissue. Fish were divided into four groups: control, propolis-treated, cypermethrin-treated, and cypermethrin+propolis-treated. Results: In fish brains, catalase (CAT) activity decreased (P≤0.001) and malondialdehyde (MDA) level increased (P≤0.001) in cypermethrin-treated group compared to control group. In cypermethrin + propolis-treated group CAT activity increased (P≤0.001) and MDA level decreased (P≤0.001) compared to cypermethrin group. Discussion: The results demonstrated that the negative effects, observed as a result of cypermethrin treatment, could be reversed by adding supplementary propolis. Propolis may improve some biochemical markers associated with oxidative stress in fish brain, after exposure to cypermethrin. |
| first_indexed | 2024-03-07T16:43:26Z |
| format | Article |
| id | doaj.art-86af6d44169c4592a71cef0a5fdde264 |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T16:43:26Z |
| publishDate | 2013-04-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-86af6d44169c4592a71cef0a5fdde2642024-03-03T07:15:31ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422013-04-0142153158Role of Propolis on Oxidative Stress in Fish BrainShapour Kakoolaki0Zeliha Selamoglu1Talas Oguz2Oguz Cakir3Osman Ciftci4Ilknur Ozdemir5 Introduction: Cypermethrin causes its neurotoxic effect through voltage-dependent sodium channels and integral protein ATPases in the neuronal membrane. Brain and nerve damage are often associated with low residual level of pesticides. In vitro and in vivo studies have also shown that pesticides cause free radical-mediated tissue damage in brain. Propolis has antioxidant properties. The main chemical classes found in propolis are flavonoids and phenolics. Bioflavonoids are antioxidant molecules that play important roles in scavenging free radicals, which are produced in neurodegenerative diseases and aging. Methods: To determine the protective role of propolis, rainbow trouts were treated with cypermethrin, followed by biochemical analyses of brain tissue. Fish were divided into four groups: control, propolis-treated, cypermethrin-treated, and cypermethrin+propolis-treated. Results: In fish brains, catalase (CAT) activity decreased (P≤0.001) and malondialdehyde (MDA) level increased (P≤0.001) in cypermethrin-treated group compared to control group. In cypermethrin + propolis-treated group CAT activity increased (P≤0.001) and MDA level decreased (P≤0.001) compared to cypermethrin group. Discussion: The results demonstrated that the negative effects, observed as a result of cypermethrin treatment, could be reversed by adding supplementary propolis. Propolis may improve some biochemical markers associated with oxidative stress in fish brain, after exposure to cypermethrin.http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-155&slc_lang=en&sid=1BrainCypermethrinOxidative StressPropolisRainbow Trout. |
| spellingShingle | Shapour Kakoolaki Zeliha Selamoglu Talas Oguz Oguz Cakir Osman Ciftci Ilknur Ozdemir Role of Propolis on Oxidative Stress in Fish Brain Basic and Clinical Neuroscience Brain Cypermethrin Oxidative Stress Propolis Rainbow Trout. |
| title | Role of Propolis on Oxidative Stress in Fish Brain |
| title_full | Role of Propolis on Oxidative Stress in Fish Brain |
| title_fullStr | Role of Propolis on Oxidative Stress in Fish Brain |
| title_full_unstemmed | Role of Propolis on Oxidative Stress in Fish Brain |
| title_short | Role of Propolis on Oxidative Stress in Fish Brain |
| title_sort | role of propolis on oxidative stress in fish brain |
| topic | Brain Cypermethrin Oxidative Stress Propolis Rainbow Trout. |
| url | http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-155&slc_lang=en&sid=1 |
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