The emerging role of SPOP protein in tumorigenesis and cancer therapy

The emerging role of SPOP protein in tumorigenesis and cancer therapy

Abstract The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis and cancer progression. Numerous studies have determined that SPOP suppresses tum...

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Bibliographic Details
Main Authors: Yizuo Song, Yichi Xu, Chunyu Pan, Linzhi Yan, Zhi-wei Wang, Xueqiong Zhu
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Molecular Cancer
Subjects:
SPOP
Oncoprotein
Tumor suppressor
Cancer
Therapy
Online Access:https://doi.org/10.1186/s12943-019-1124-x

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