Clinical utility of early amplitude integrated EEG in monitoring term newborns at risk of neurological injury
Objective: to test the clinical utility of an early amplitude-integrated electroencephalography (aEEG) to predict short-term neurological outcome in term newborns at risk of neurology injury. Methods: this was a prospective, descriptive study. The inclusion criteria were neonatal encephalopathy, neu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Portuguese |
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Brazilian Society of Pediatrics
2014-03-01
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| Series: | Jornal de Pediatria (Versão em Português) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2255553614000378 |
| _version_ | 1811255180482576384 |
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| author | Paulina A. Toso Alvaro J. González María E. Pérez Javier Kattan Jorge G. Fabres José L. Tapia Hernán S. González |
| author_facet | Paulina A. Toso Alvaro J. González María E. Pérez Javier Kattan Jorge G. Fabres José L. Tapia Hernán S. González |
| author_sort | Paulina A. Toso |
| collection | DOAJ |
| description | Objective: to test the clinical utility of an early amplitude-integrated electroencephalography (aEEG) to predict short-term neurological outcome in term newborns at risk of neurology injury.
Methods: this was a prospective, descriptive study. The inclusion criteria were neonatal encephalopathy, neurologic disturbances, and severe respiratory distress syndrome. Sensitivity, specificity, positive and negative predictive values, and likelihood ratio (LR) were calculated. Clinical and demographic data were analyzed. Neurological outcome was defined as the sum of clinical, electroimaging, and neuroimaging findings.
Results: ten of the 21 monitored infants (48%) presented altered short-term neurologic out-come. The aEEG had 90% sensitivity, 82% specificity, 82% positive predictive value, and 90% negative predictive value. The positive LR was 4.95, and the negative LR was 0.12. In three of12 (25%) encephalopathic infants, the aEEG allowed for a better definition of the severity of their condition. Seizures were detected in eight infants (38%), all subclinical at baseline, and none had a normal aEEG background pattern. The status of three infants (43%) evolved and required two or more drugs for treatment.
Conclusions: in infants with encephalopathy or other severe illness, aEEG disturbances occur frequently. aEEG provided a better classification of the severity of encephalopathy, detectedearly subclinical seizures, and allowed for monitoring of the response to treatment. aEEG was a useful tool at the neonatal intensive care unit for predicting poor short-term neurologicaloutcomes for all sick newborn. |
| first_indexed | 2024-04-12T17:19:53Z |
| format | Article |
| id | doaj.art-86b66d8ea7fa449a882e6335e2614e22 |
| institution | Directory Open Access Journal |
| issn | 2255-5536 |
| language | Portuguese |
| last_indexed | 2024-04-12T17:19:53Z |
| publishDate | 2014-03-01 |
| publisher | Brazilian Society of Pediatrics |
| record_format | Article |
| series | Jornal de Pediatria (Versão em Português) |
| spelling | doaj.art-86b66d8ea7fa449a882e6335e2614e222022-12-22T03:23:31ZporBrazilian Society of PediatricsJornal de Pediatria (Versão em Português)2255-55362014-03-0190214314810.1016/j.jpedp.2013.07.005Clinical utility of early amplitude integrated EEG in monitoring term newborns at risk of neurological injuryPaulina A. Toso0Alvaro J. González1María E. Pérez2Javier Kattan3Jorge G. Fabres4José L. Tapia5Hernán S. González6Divisão de Pediatria, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileDivisão de Pediatria, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChilePontificia Universidad Católica de Chile, Santiago, ChileDivisão de Pediatria, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileDivisão de Pediatria, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileDivisão de Pediatria, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileDivisão de Pediatria, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileObjective: to test the clinical utility of an early amplitude-integrated electroencephalography (aEEG) to predict short-term neurological outcome in term newborns at risk of neurology injury. Methods: this was a prospective, descriptive study. The inclusion criteria were neonatal encephalopathy, neurologic disturbances, and severe respiratory distress syndrome. Sensitivity, specificity, positive and negative predictive values, and likelihood ratio (LR) were calculated. Clinical and demographic data were analyzed. Neurological outcome was defined as the sum of clinical, electroimaging, and neuroimaging findings. Results: ten of the 21 monitored infants (48%) presented altered short-term neurologic out-come. The aEEG had 90% sensitivity, 82% specificity, 82% positive predictive value, and 90% negative predictive value. The positive LR was 4.95, and the negative LR was 0.12. In three of12 (25%) encephalopathic infants, the aEEG allowed for a better definition of the severity of their condition. Seizures were detected in eight infants (38%), all subclinical at baseline, and none had a normal aEEG background pattern. The status of three infants (43%) evolved and required two or more drugs for treatment. Conclusions: in infants with encephalopathy or other severe illness, aEEG disturbances occur frequently. aEEG provided a better classification of the severity of encephalopathy, detectedearly subclinical seizures, and allowed for monitoring of the response to treatment. aEEG was a useful tool at the neonatal intensive care unit for predicting poor short-term neurologicaloutcomes for all sick newborn.http://www.sciencedirect.com/science/article/pii/S2255553614000378Amplitude integrated electroencephalography (aEEG)Hypoxic ischemic encephalopathy (HIE)Neonatal intensive careSeizures |
| spellingShingle | Paulina A. Toso Alvaro J. González María E. Pérez Javier Kattan Jorge G. Fabres José L. Tapia Hernán S. González Clinical utility of early amplitude integrated EEG in monitoring term newborns at risk of neurological injury Jornal de Pediatria (Versão em Português) Amplitude integrated electroencephalography (aEEG) Hypoxic ischemic encephalopathy (HIE) Neonatal intensive care Seizures |
| title | Clinical utility of early amplitude integrated EEG in monitoring term newborns at risk of neurological injury |
| title_full | Clinical utility of early amplitude integrated EEG in monitoring term newborns at risk of neurological injury |
| title_fullStr | Clinical utility of early amplitude integrated EEG in monitoring term newborns at risk of neurological injury |
| title_full_unstemmed | Clinical utility of early amplitude integrated EEG in monitoring term newborns at risk of neurological injury |
| title_short | Clinical utility of early amplitude integrated EEG in monitoring term newborns at risk of neurological injury |
| title_sort | clinical utility of early amplitude integrated eeg in monitoring term newborns at risk of neurological injury |
| topic | Amplitude integrated electroencephalography (aEEG) Hypoxic ischemic encephalopathy (HIE) Neonatal intensive care Seizures |
| url | http://www.sciencedirect.com/science/article/pii/S2255553614000378 |
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