Protein O-GlcNAcylation in Cardiac Pathologies: Past, Present, Future
O-GlcNAcylation is a ubiquitous and reversible post-translational protein modification that has recently gained renewed interest due to the rapid development of analytical tools and new molecules designed to specifically increase the level of protein O-GlcNAcylation. The level of O-GlcNAc modificati...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-01-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2018.00819/full |
| _version_ | 1818061457622827008 |
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| author | Marine Ferron Marine Ferron Manon Denis Antoine Persello Raahulan Rathagirishnan Benjamin Lauzier |
| author_facet | Marine Ferron Marine Ferron Manon Denis Antoine Persello Raahulan Rathagirishnan Benjamin Lauzier |
| author_sort | Marine Ferron |
| collection | DOAJ |
| description | O-GlcNAcylation is a ubiquitous and reversible post-translational protein modification that has recently gained renewed interest due to the rapid development of analytical tools and new molecules designed to specifically increase the level of protein O-GlcNAcylation. The level of O-GlcNAc modification appears to have either deleterious or beneficial effects, depending on the context (exposure time, pathophysiological context). While high O-GlcNAcylation levels are mostly reported in chronic diseases, the increase in O-GlcNAc level in acute stresses such as during ischemia reperfusion or hemorrhagic shock is reported to be beneficial in vitro, ex vivo, or in vivo. In this context, an increase in O-GlcNAc levels could be a potential new cardioprotective therapy, but the ambivalent effects of protein O-GlcNAcylation augmentation remains as a key problem to be solved prior to their transfer to the clinic. The emergence of new analytical tools has opened new avenues to decipher the mechanisms underlying the beneficial effects associated with an O-GlcNAc level increase. A better understanding of the exact roles of O-GlcNAc on protein function, targeting or stability will help to develop more targeted approaches. The aim of this review is to discuss the mechanisms and potential beneficial impact of O-GlcNAc modulation, and its potential as a new clinical target in cardiology. |
| first_indexed | 2024-12-10T13:48:37Z |
| format | Article |
| id | doaj.art-86b6d5cdd75c4b4fa06415174cc27b88 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-10T13:48:37Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-86b6d5cdd75c4b4fa06415174cc27b882022-12-22T01:46:20ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-01-01910.3389/fendo.2018.00819414284Protein O-GlcNAcylation in Cardiac Pathologies: Past, Present, FutureMarine Ferron0Marine Ferron1Manon Denis2Antoine Persello3Raahulan Rathagirishnan4Benjamin Lauzier5Montreal Heart Institute, Montreal, QC, Canadal'institut du thorax, INSERM, CNRS, UNIV Nantes, Nantes, Francel'institut du thorax, INSERM, CNRS, UNIV Nantes, Nantes, Francel'institut du thorax, INSERM, CNRS, UNIV Nantes, Nantes, FranceFaculty of Health Sciences, University of Ottawa, Ottawa, ON, Canadal'institut du thorax, INSERM, CNRS, UNIV Nantes, Nantes, FranceO-GlcNAcylation is a ubiquitous and reversible post-translational protein modification that has recently gained renewed interest due to the rapid development of analytical tools and new molecules designed to specifically increase the level of protein O-GlcNAcylation. The level of O-GlcNAc modification appears to have either deleterious or beneficial effects, depending on the context (exposure time, pathophysiological context). While high O-GlcNAcylation levels are mostly reported in chronic diseases, the increase in O-GlcNAc level in acute stresses such as during ischemia reperfusion or hemorrhagic shock is reported to be beneficial in vitro, ex vivo, or in vivo. In this context, an increase in O-GlcNAc levels could be a potential new cardioprotective therapy, but the ambivalent effects of protein O-GlcNAcylation augmentation remains as a key problem to be solved prior to their transfer to the clinic. The emergence of new analytical tools has opened new avenues to decipher the mechanisms underlying the beneficial effects associated with an O-GlcNAc level increase. A better understanding of the exact roles of O-GlcNAc on protein function, targeting or stability will help to develop more targeted approaches. The aim of this review is to discuss the mechanisms and potential beneficial impact of O-GlcNAc modulation, and its potential as a new clinical target in cardiology.https://www.frontiersin.org/article/10.3389/fendo.2018.00819/fullO-GlcNAccardiovascularischemia-reperfusionpharmacologytherapy |
| spellingShingle | Marine Ferron Marine Ferron Manon Denis Antoine Persello Raahulan Rathagirishnan Benjamin Lauzier Protein O-GlcNAcylation in Cardiac Pathologies: Past, Present, Future Frontiers in Endocrinology O-GlcNAc cardiovascular ischemia-reperfusion pharmacology therapy |
| title | Protein O-GlcNAcylation in Cardiac Pathologies: Past, Present, Future |
| title_full | Protein O-GlcNAcylation in Cardiac Pathologies: Past, Present, Future |
| title_fullStr | Protein O-GlcNAcylation in Cardiac Pathologies: Past, Present, Future |
| title_full_unstemmed | Protein O-GlcNAcylation in Cardiac Pathologies: Past, Present, Future |
| title_short | Protein O-GlcNAcylation in Cardiac Pathologies: Past, Present, Future |
| title_sort | protein o glcnacylation in cardiac pathologies past present future |
| topic | O-GlcNAc cardiovascular ischemia-reperfusion pharmacology therapy |
| url | https://www.frontiersin.org/article/10.3389/fendo.2018.00819/full |
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