Role of epigenetics in the etiology of hypospadias through penile foreskin DNA methylation alterations

Abstract Abnormal penile foreskin development in hypospadias is the most frequent genital malformation in male children, which has increased dramatically in recent decades. A number of environmental factors have been shown to be associated with hypospadias development. The current study investigated...

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Bibliographic Details
Main Authors: Martin Kaefer, Richard Rink, Rosalia Misseri, Paul Winchester, Cathy Proctor, Millissia Ben Maamar, Daniel Beck, Eric Nilsson, Michael K. Skinner
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-27763-5