Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells.
The presence of m6A in mRNA of METTL3 knockout cells has long been a point of confusion. In this issue of PLOS Biology, Poh and colleagues reveal alternatively spliced, catalytically active METTL3 isoforms that persist in cells previously thought to lack the enzyme.
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-07-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3001717 |
| _version_ | 1818496729661571072 |
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| author | Sigrid Nachtergaele |
| author_facet | Sigrid Nachtergaele |
| author_sort | Sigrid Nachtergaele |
| collection | DOAJ |
| description | The presence of m6A in mRNA of METTL3 knockout cells has long been a point of confusion. In this issue of PLOS Biology, Poh and colleagues reveal alternatively spliced, catalytically active METTL3 isoforms that persist in cells previously thought to lack the enzyme. |
| first_indexed | 2024-12-10T18:36:31Z |
| format | Article |
| id | doaj.art-86b7e69a86de490f90bf39650e0be134 |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-10T18:36:31Z |
| publishDate | 2022-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-86b7e69a86de490f90bf39650e0be1342022-12-22T01:37:47ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852022-07-01207e300171710.1371/journal.pbio.3001717Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells.Sigrid NachtergaeleThe presence of m6A in mRNA of METTL3 knockout cells has long been a point of confusion. In this issue of PLOS Biology, Poh and colleagues reveal alternatively spliced, catalytically active METTL3 isoforms that persist in cells previously thought to lack the enzyme.https://doi.org/10.1371/journal.pbio.3001717 |
| spellingShingle | Sigrid Nachtergaele Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells. PLoS Biology |
| title | Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells. |
| title_full | Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells. |
| title_fullStr | Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells. |
| title_full_unstemmed | Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells. |
| title_short | Enzymes flying under the radar: Cryptic METTL3 can persist in knockout cells. |
| title_sort | enzymes flying under the radar cryptic mettl3 can persist in knockout cells |
| url | https://doi.org/10.1371/journal.pbio.3001717 |
| work_keys_str_mv | AT sigridnachtergaele enzymesflyingundertheradarcrypticmettl3canpersistinknockoutcells |