The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis
Polycystic ovary syndrome (PCOS) and endometriosis are frequent diseases of the female reproductive tract causing high morbidity as they can significantly affect fertility and quality of life. Adipokines are pleiotropic signaling molecules secreted by white or brown adipose tissues with a central ro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/10/2503 |
| _version_ | 1827651390699208704 |
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| author | Susanne Schüler-Toprak Olaf Ortmann Christa Buechler Oliver Treeck |
| author_facet | Susanne Schüler-Toprak Olaf Ortmann Christa Buechler Oliver Treeck |
| author_sort | Susanne Schüler-Toprak |
| collection | DOAJ |
| description | Polycystic ovary syndrome (PCOS) and endometriosis are frequent diseases of the female reproductive tract causing high morbidity as they can significantly affect fertility and quality of life. Adipokines are pleiotropic signaling molecules secreted by white or brown adipose tissues with a central role in energy metabolism. More recently, their involvement in PCOS and endometriosis has been demonstrated. In this review article, we provide an update on the role of adipokines in both diseases and summarize previous findings. We also address the results of multi-omics approaches in adipokine research to examine the role of single nucleotide polymorphisms (SNPs) in genes coding for adipokines and their receptors, the secretome of adipocytes and to identify epigenetic alterations of adipokine genes that might be conferred from mother to child. Finally, we address novel data on the role of brown adipose tissue (BAT), which seems to have notable effects on PCOS. For this review, original research articles on adipokine actions in PCOS and endometriosis are considered, which are listed in the PubMed database. |
| first_indexed | 2024-03-09T20:39:02Z |
| format | Article |
| id | doaj.art-86b9a877036845e18d987405da0d9810 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:39:02Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-86b9a877036845e18d987405da0d98102023-11-23T23:04:05ZengMDPI AGBiomedicines2227-90592022-10-011010250310.3390/biomedicines10102503The Complex Roles of Adipokines in Polycystic Ovary Syndrome and EndometriosisSusanne Schüler-Toprak0Olaf Ortmann1Christa Buechler2Oliver Treeck3Department of Gynecology and Obstetrics, University Medical Center Regensburg, 93053 Regensburg, GermanyDepartment of Gynecology and Obstetrics, University Medical Center Regensburg, 93053 Regensburg, GermanyDepartment of Internal Medicine I, University Medical Center Regensburg, 93053 Regensburg, GermanyDepartment of Gynecology and Obstetrics, University Medical Center Regensburg, 93053 Regensburg, GermanyPolycystic ovary syndrome (PCOS) and endometriosis are frequent diseases of the female reproductive tract causing high morbidity as they can significantly affect fertility and quality of life. Adipokines are pleiotropic signaling molecules secreted by white or brown adipose tissues with a central role in energy metabolism. More recently, their involvement in PCOS and endometriosis has been demonstrated. In this review article, we provide an update on the role of adipokines in both diseases and summarize previous findings. We also address the results of multi-omics approaches in adipokine research to examine the role of single nucleotide polymorphisms (SNPs) in genes coding for adipokines and their receptors, the secretome of adipocytes and to identify epigenetic alterations of adipokine genes that might be conferred from mother to child. Finally, we address novel data on the role of brown adipose tissue (BAT), which seems to have notable effects on PCOS. For this review, original research articles on adipokine actions in PCOS and endometriosis are considered, which are listed in the PubMed database.https://www.mdpi.com/2227-9059/10/10/2503polycystic ovary syndromeendometriosisadipokinebatokinewhite adipose tissuebrown adipose tissue |
| spellingShingle | Susanne Schüler-Toprak Olaf Ortmann Christa Buechler Oliver Treeck The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis Biomedicines polycystic ovary syndrome endometriosis adipokine batokine white adipose tissue brown adipose tissue |
| title | The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis |
| title_full | The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis |
| title_fullStr | The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis |
| title_full_unstemmed | The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis |
| title_short | The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis |
| title_sort | complex roles of adipokines in polycystic ovary syndrome and endometriosis |
| topic | polycystic ovary syndrome endometriosis adipokine batokine white adipose tissue brown adipose tissue |
| url | https://www.mdpi.com/2227-9059/10/10/2503 |
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