Impaired cerebral oxygenation in heart failure patients at rest and during head‐up tilt testing
Abstract Aims Heart failure (HF) confers potentially negative effects on the brain and autonomic nervous system. The measurement cerebral tissue oxygen saturation (SctO2) may aid in understanding such effects. We aimed to investigate if compensated HF affects SctO2 at rest and during orthostatic cha...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-02-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.13128 |
| _version_ | 1828890275666198528 |
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| author | Isabella Kharraziha Hannes Holm Martin Magnusson Per Wollmer John Molvin Amra Jujic Artur Fedorowski Erasmus Bachus Viktor Hamrefors |
| author_facet | Isabella Kharraziha Hannes Holm Martin Magnusson Per Wollmer John Molvin Amra Jujic Artur Fedorowski Erasmus Bachus Viktor Hamrefors |
| author_sort | Isabella Kharraziha |
| collection | DOAJ |
| description | Abstract Aims Heart failure (HF) confers potentially negative effects on the brain and autonomic nervous system. The measurement cerebral tissue oxygen saturation (SctO2) may aid in understanding such effects. We aimed to investigate if compensated HF affects SctO2 at rest and during orthostatic challenge. Methods and results Non‐invasive haemodynamic monitoring and near‐infrared spectroscopy were applied during head‐up tilt (HUT) in 61 HF patients [mean (SD) 71 (11) years, 82% male, New York Heart Association (NYHA) class I–III] and 60 controls [60 (12) years, 42% male). Group differences in continuous variables were compared using Student's t‐test. Associations between HF and SctO2 were studied using multivariable linear regression models adjusted for age, sex, diabetes, smoking, systolic blood pressure (SBP), and heart rate in supine position and after 10 min of HUT. Mean SctO2 was lower in HF patients compared with controls both in the supine position (67 vs. 71%; P < 0.001) and after 10 min of HUT (64 vs. 69%; P < 0.001). The HUT‐induced SctO2 decrease was greater in HF patients compared with controls (P = 0.026). SBP did not change in neither HF patients nor controls during HUT, whereas diastolic blood pressure and heart rate increased in both groups. HF was associated with lower SctO2 in supine (B = −2.5%, P = 0.023) and after 10 min of HUT (B = −2.6%, P = 0.007) after multivariable adjustments. Conclusions Cerebral tissue oxygenation is lower in HF patients both at rest and during orthostasis compared with subjects without HF. Future studies should test if the lower cerebral oxygenation associates with negative prognosis and with impaired cognitive function. |
| first_indexed | 2024-12-13T12:55:57Z |
| format | Article |
| id | doaj.art-86b9d54c375c4a8099c8681e26040f3f |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-12-13T12:55:57Z |
| publishDate | 2021-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-86b9d54c375c4a8099c8681e26040f3f2022-12-21T23:45:11ZengWileyESC Heart Failure2055-58222021-02-018158659410.1002/ehf2.13128Impaired cerebral oxygenation in heart failure patients at rest and during head‐up tilt testingIsabella Kharraziha0Hannes Holm1Martin Magnusson2Per Wollmer3John Molvin4Amra Jujic5Artur Fedorowski6Erasmus Bachus7Viktor Hamrefors8Department of Clinical Sciences Lund University Malmö 20213 SwedenDepartment of Clinical Sciences Lund University Malmö 20213 SwedenDepartment of Clinical Sciences Lund University Malmö 20213 SwedenDepartment of Translational Medicine Lund University Malmö SwedenDepartment of Clinical Sciences Lund University Malmö 20213 SwedenDepartment of Clinical Sciences Lund University Malmö 20213 SwedenDepartment of Clinical Sciences Lund University Malmö 20213 SwedenDepartment of Clinical Sciences Lund University Malmö 20213 SwedenDepartment of Clinical Sciences Lund University Malmö 20213 SwedenAbstract Aims Heart failure (HF) confers potentially negative effects on the brain and autonomic nervous system. The measurement cerebral tissue oxygen saturation (SctO2) may aid in understanding such effects. We aimed to investigate if compensated HF affects SctO2 at rest and during orthostatic challenge. Methods and results Non‐invasive haemodynamic monitoring and near‐infrared spectroscopy were applied during head‐up tilt (HUT) in 61 HF patients [mean (SD) 71 (11) years, 82% male, New York Heart Association (NYHA) class I–III] and 60 controls [60 (12) years, 42% male). Group differences in continuous variables were compared using Student's t‐test. Associations between HF and SctO2 were studied using multivariable linear regression models adjusted for age, sex, diabetes, smoking, systolic blood pressure (SBP), and heart rate in supine position and after 10 min of HUT. Mean SctO2 was lower in HF patients compared with controls both in the supine position (67 vs. 71%; P < 0.001) and after 10 min of HUT (64 vs. 69%; P < 0.001). The HUT‐induced SctO2 decrease was greater in HF patients compared with controls (P = 0.026). SBP did not change in neither HF patients nor controls during HUT, whereas diastolic blood pressure and heart rate increased in both groups. HF was associated with lower SctO2 in supine (B = −2.5%, P = 0.023) and after 10 min of HUT (B = −2.6%, P = 0.007) after multivariable adjustments. Conclusions Cerebral tissue oxygenation is lower in HF patients both at rest and during orthostasis compared with subjects without HF. Future studies should test if the lower cerebral oxygenation associates with negative prognosis and with impaired cognitive function.https://doi.org/10.1002/ehf2.13128Heart failureCerebral oximetryHead‐up tilt testOrthostatic provocation |
| spellingShingle | Isabella Kharraziha Hannes Holm Martin Magnusson Per Wollmer John Molvin Amra Jujic Artur Fedorowski Erasmus Bachus Viktor Hamrefors Impaired cerebral oxygenation in heart failure patients at rest and during head‐up tilt testing ESC Heart Failure Heart failure Cerebral oximetry Head‐up tilt test Orthostatic provocation |
| title | Impaired cerebral oxygenation in heart failure patients at rest and during head‐up tilt testing |
| title_full | Impaired cerebral oxygenation in heart failure patients at rest and during head‐up tilt testing |
| title_fullStr | Impaired cerebral oxygenation in heart failure patients at rest and during head‐up tilt testing |
| title_full_unstemmed | Impaired cerebral oxygenation in heart failure patients at rest and during head‐up tilt testing |
| title_short | Impaired cerebral oxygenation in heart failure patients at rest and during head‐up tilt testing |
| title_sort | impaired cerebral oxygenation in heart failure patients at rest and during head up tilt testing |
| topic | Heart failure Cerebral oximetry Head‐up tilt test Orthostatic provocation |
| url | https://doi.org/10.1002/ehf2.13128 |
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