Structural Insights into the Role of β3 nAChR Subunit in the Activation of Nicotinic Receptors

Structural Insights into the Role of β3 nAChR Subunit in the Activation of Nicotinic Receptors

The β3 subunit of nicotinic acetylcholine receptors (nAChRs) participates in heteropentameric assemblies with some α and other β neuronal subunits forming a plethora of various subtypes, differing in their electrophysiological and pharmacological properties. While β3 has for several years been consi...

Full description

Bibliographic Details
Main Authors:	Petros Giastas, Athanasios Papakyriakou, George Tsafaras, Socrates J. Tzartos, Marios Zouridakis
Format:	Article
Language:	English
Published:	MDPI AG 2022-07-01
Series:	Molecules
Subjects:	nAChR pentameric ligand gated ion channels pentamers principal binding site complementary binding site α4β2 nAChR
Online Access:	https://www.mdpi.com/1420-3049/27/14/4642

Similar Items

Immunohistochemical detection and regulation of α<sub>5 </sub>nicotinic acetylcholine receptor (nAChR) subunits by FoxA2 during mouse lung organogenesis
by: Willnauer Charles P, et al.
Published: (2011-06-01)

Interaction of agonists of a different subtype of the nAChR and carvacrol with GABA in Ascaris suum somatic muscle contractions
by: Djordje S. Marjanović, et al.
Published: (2021-02-01)

Evaluation of galantamine and deconstructed analogs as α7 nAChR and AChE ligands
by: Malaika D. Argade, et al.
Published: (2022-01-01)

Smoking-mediated nicotinic acetylcholine receptors (nAChRs) for predicting outcomes for head and neck squamous cell carcinomas
by: Yujie Shen, et al.
Published: (2022-10-01)

Modulation of the Effect of Cisplatin on Nicotine-Stimulated A549 Lung Cancer Cells Using Analog of Marine Sponge Toxin Loaded in Gelatin Nanoparticles
by: Ahmad Joukhan, et al.
Published: (2024-04-01)

Comparative functional expression of nAChR subtypes in rodent DRG neurons
by: Nathan J. Smith, et al.
Published: (2013-11-01)

Activation of α7nAChR by PNU282987 improves cognitive impairment through inhibiting oxidative stress and neuroinflammation in D-galactose induced aging via regulating α7nAChR/Nrf2/HO-1 signaling pathway
by: Yawen Zhang, et al.
Published: (2023-05-01)

Residues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRs
by: Bo Lin, et al.
Published: (2016-10-01)

α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect
by: Huiyang Liu, et al.
Published: (2023-03-01)

Nicotine Increases Macrophage Survival through α7nAChR/NF-κB Pathway in <i>Mycobacterium</i> <i>avium</i> <i>paratuberculosis</i> Infection
by: Dania AlQasrawi, et al.
Published: (2021-05-01)

Target identification and validation of the alpha7 nicotinic acetylcholine receptor as a potential therapeutic target in retinal disease
by: David M. Linn
Published: (2023-07-01)

An Investigation of Three-Finger Toxin—nAChR Interactions through Rosetta Protein Docking
by: Alican Gulsevin, et al.
Published: (2020-09-01)

Cullin-3 intervenes in muscle atrophy in the elderly by mediating the degradation of nAchRs ubiquitination
by: Jintao Chen, et al.
Published: (2023-11-01)

In silico approaches for developing sesquiterpene derivatives as antagonists of human nicotinic acetylcholine receptors (nAChRs) for nicotine addiction treatment
by: Taufik Muhammad Fakih, et al.
Published: (2025-06-01)

αD-Conotoxins in Species of the Eastern Pacific: The Case of <i>Conus princeps</i> from Mexico
by: Arisaí C. Hernández-Sámano, et al.
Published: (2019-07-01)

α5-nAChR/NETO2 contributed to chronic stress-promoted lung adenocarcinoma progression
by: Jingting Wang, et al.
Published: (2025-02-01)

Short-Term High-Fat Diet Consumption Reduces Hypothalamic Expression of the Nicotinic Acetylcholine Receptor α7 Subunit (α7nAChR) and Affects the Anti-inflammatory Response in a Mouse Model of Sepsis
by: Anelise Cristina Parras Souza, et al.
Published: (2019-03-01)

Venom-Derived Neurotoxins Targeting Nicotinic Acetylcholine Receptors
by: Ayaulym Bekbossynova, et al.
Published: (2021-06-01)

E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation
by: Qixin Wang, et al.
Published: (2020-06-01)

Comparison between imidacloprid effects on AChE and nAChRα1 in target Aphis craccivora and non-target Apis mellifera: experimental and theoretical approaches
by: Hussein M. Ali, et al.
Published: (2024-08-01)

Beneficial effects of anisodamine in shock involved nicotinic anti-inflammatory pathway
by: Ting eZhao, et al.
Published: (2011-05-01)

Anisodamine ameliorates crystalline silica-exposed pulmonary inflammation and fibrosis via the α7nAChR/JAK2/STAT3 signaling pathway
by: Meng Liu, et al.
Published: (2025-01-01)

Nicotinic acetylcholine receptor-mediated effects of varenicline on LPS-elevated prostaglandin and cyclooxygenase levels in RAW 264.7 macrophages
by: Elif Baris, et al.
Published: (2024-05-01)

Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors
by: Thao NT Ho, et al.
Published: (2023-04-01)

Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption
by: Marta A Ślimak, et al.
Published: (2014-01-01)

Swimming exercise and clove oil can improve memory by molecular responses modification and reduce dark cells in rat model of Alzheimer's disease
by: Z. Gorgin Karaji, et al.
Published: (2023-06-01)

Drosophila nicotinic acetylcholine receptor subunits and their native interactions with insecticidal peptide toxins
by: Dagmara Korona, et al.
Published: (2022-05-01)

α-Conotoxin TxID and [S9K]TxID, α3β4 nAChR Antagonists, Attenuate Expression and Reinstatement of Nicotine-Induced Conditioned Place Preference in Mice
by: Xiaodan Li, et al.
Published: (2020-12-01)

Attenuation of Nicotine Effects on A549 Lung Cancer Cells by Synthetic α7 nAChR Antagonists APS7-2 and APS8-2
by: Ahmad Joukhan, et al.
Published: (2024-03-01)

Activation of the α7 Nicotinic Acetylcholine Receptor Prevents against Microglial-Induced Inflammation and Insulin Resistance in Hypothalamic Neuronal Cells
by: Camila Libardi do Amaral, et al.
Published: (2022-07-01)

Efecto modulador de los glucocorticoides sobre la angiogénesis mediada por PI3K/Akt activada por α7-nAChR: Una revisión narrativa
by: Matías Latorre de Halleux, et al.
Published: (2024-06-01)

Toward an Innovative Treatment of Alzheimer’s Disease: Design of MTDLs Targeting Acetylcholinesterase and α-7 Nicotinic Receptors
by: Mégane Pons, et al.
Published: (2019-08-01)

Targeting α7 nicotinic acetylcholine receptors for chronic pain
by: Ya-Qun Zhou, et al.
Published: (2022-09-01)

Efficient Expression in <i>Leishmania tarentolae</i> (LEXSY) of the Receptor-Binding Domain of the SARS-CoV-2 S-Protein and the Acetylcholine-Binding Protein from <i>Lymnaea stagnalis</i>
by: Lina Son, et al.
Published: (2024-02-01)

Physiologic Functions and Therapeutic Applications of α7 Nicotinic Acetylcholine Receptor in Brain Disorders
by: Chien-Hsing Lee, et al.
Published: (2022-12-01)

Insights into Crystallization of Neuronal Nicotinic α4β2 Receptor in Polarized Lipid Matrices
by: Juan C. Villalobos-Santos, et al.
Published: (2024-10-01)

Minimal Structural Changes Determine Full and Partial Nicotinic Receptor Agonist Activity for Nicotine Analogues
by: Juan Pablo Gonzalez-Gutierrez, et al.
Published: (2019-07-01)

Modulation of Ca2+ oscillation following ischemia and nicotinic acetylcholine receptors in primary cortical neurons by high-throughput analysis
by: Tsutomu Sasaki, et al.
Published: (2024-11-01)

Roles of alpha-7 nicotinic acetylcholine receptors and spleen in the lung injury induced by a repeated saline lavage in rat
by: Hossein Fatemikia, et al.
Published: (2022-09-01)

Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3β4 Nicotinic Acetylcholine Receptor
by: Yuan Ma, et al.
Published: (2022-07-01)