Transcriptional Coactivator BOB1 (OBF1, OCA-B) Modulates the Specificity of DNA Recognition by the POU-Domain Factors OCT1 and OCT2 in a Monomeric Configuration

Transcriptional Coactivator BOB1 (OBF1, OCA-B) Modulates the Specificity of DNA Recognition by the POU-Domain Factors OCT1 and OCT2 in a Monomeric Configuration

BOB1, a mammalian lymphocyte-specific transcriptional coactivator of the transcription factors OCT1 and OCT2 (OCT1/2), plays important roles in normal immune responses, autoimmunity, and hematologic malignancies. The issue of a DNA sequence preference change imposed by BOB1 was raised more than two...

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Bibliographic Details
Main Authors: Igor B. Nazarov, Danil S. Zilov, Mikhail N. Gordeev, Evgenii V. Potapenko, Nataliya Yeremenko, Alexey N. Tomilin
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Biomolecules
Subjects:
BOB1
OCA-B
OBF1
OCT1
OCT2
transcription factor specificity
Online Access:https://www.mdpi.com/2218-273X/14/1/123

Internet

https://www.mdpi.com/2218-273X/14/1/123

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